International Ophthalmology

, Volume 38, Issue 5, pp 1817–1823 | Cite as

Serum and aqueous humor concentrations of interleukin-27 in diabetic retinopathy patients

  • Maha E. Houssen
  • Mona Abo Bakr El-Hussiny
  • Amr El-Kannishy
  • Dalia Sabry
  • Rasha El Mahdy
  • Mohamed E. ShakerEmail author
Original Paper



Interleukin (IL)-27 has been reported to possess anti- and proinflammatory properties in several immune related-disorders, but its role in diabetic retinopathy is still elusive. Here, we aimed to (i) evaluate IL-27 concentrations in serum and aqueous humor of diabetic patients with or without retinopathy and (ii) test whether IL-27 is correlated with some risk factors of diabetic retinopathy.


The study comprised 60 diabetic patients with and without retinopathy along with 20 healthy controls. Serum and aqueous humor concentrations of IL-27 were assessed by ELISA.


The mean of IL-27 concentration in aqueous humor in patients with diabetic retinopathy (6.7 ± 2.7 ng/L) was significantly elevated in comparison with either diabetic patients without retinopathy (4.6 ± 0.5 ng/L) or healthy control group (4.1 ± 0.8 ng/L). Besides, IL-27 concentration in aqueous humor was positively correlated with serum glucose, lipid profile and glycated hemoglobin (HbA1c).


Based on this study, IL-27 is implicated in the pathogenesis of diabetic retinopathy and positively correlates with the disorder progression.


Diabetic retinopathy IL-27 Glycated hemoglobin Cholesterol Triglycerides 


Compliance with ethical standards

Conflict of interest

The authors report no conflicts of interest to disclose.


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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Maha E. Houssen
    • 1
  • Mona Abo Bakr El-Hussiny
    • 2
  • Amr El-Kannishy
    • 3
  • Dalia Sabry
    • 3
  • Rasha El Mahdy
    • 4
  • Mohamed E. Shaker
    • 5
    Email author
  1. 1.Department of Biochemistry, Faculty of PharmacyDamanhour UniversityDamanhourEgypt
  2. 2.Department of Clinical Pathology, Faculty of MedicineMansoura UniversityMansouraEgypt
  3. 3.Department of Ophthalmology, Faculty of MedicineMansoura UniversityMansouraEgypt
  4. 4.Department of Medical Microbiology and Immunology, Faculty of MedicineMansoura UniversityMansouraEgypt
  5. 5.Department of Pharmacology and Toxicology, Faculty of PharmacyMansoura UniversityMansouraEgypt

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