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Phytochemicals as potential IKK-β inhibitor for the treatment of cardiovascular diseases in plant preservation: terpenoids, alkaloids, and quinones

  • Fang Hua
  • Lingli Shi
  • Peng ZhouEmail author
Review
  • 27 Downloads

Abstract

Modulation of inhibitor kappa B kinase-beta (IKK-β) kinase activity could be useful for preventing inflammation that serves an efficient role in protection against cardiovascular diseases (CVDs). IKK-β induces inflammation by activating transcription factor NF-kappa B (NF-κB) through phosphorylation of IκB. Therefore, IKK-β is considered an interesting target for protecting and treating CVDs. The cardioprotective potential of terpenoids, alkaloids and quinines may be related to modulating inflammatory responses. In this study, the interactions between different classes of inhibitors and IKK-β were investigated, through the application of SystemsDock. Molecular docking results showed that Diosgenin and Ginsenoside Re were the top docking score compounds. Diosgenin and Ginsenoside Re are the most promising IKK-β inhibitors in terpenoids, alkaloids, and quinones. Diosgenin and Ginsenoside Re could be helpful to find the lead compounds on designing and developing novel cardioprotective agents.

Keywords

Terpenoids Alkaloids Quinones Cardiovascular diseases Ikk-β inhibitor Molecular docking 

Notes

Acknowledgements

Financial assistance was received with appreciation from the Key Project Foundation of Natural Science Research in Universities of Anhui Province in China (Nos. KJ2017A303 and KJ2017A629), and Training Object for Key Teacher of Anhui Xinhua University (Nos. 2018xgg25 and 2018xgg26).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. 1.Pharmacy SchoolAnhui Xinhua UniversityHefeiPeople’s Republic of China
  2. 2.Natural Products Laboratory, International Joint Lab of Tea Chemistry and Health Effects, State Key Laboratory of Tea Plant Biology and UtilizationAnhui Agricultural UniversityHefeiPeople’s Republic of China
  3. 3.School of Integrated Chinese and Western MedicineAnhui University of Chinese MedicineHefeiPeople’s Republic of China
  4. 4.Institute of Integrated Chinese and Western MedicineAnhui Academy of Chinese MedicineHefeiPeople’s Republic of China
  5. 5.Anhui Province Key Laboratory of Chinese Medicinal FormulaHefeiPeople’s Republic of China

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