The role of magnesium in different inflammatory diseases

  • Abbas Shahi
  • Saeed Aslani
  • MohammadReza AtaollahiEmail author
  • Mahdi MahmoudiEmail author


Magnesium deficiency (MgD) can cause inflammation in human body. The known mechanisms of inflammation caused by MgD include activation of phagocytic cells, opening of calcium channels, activation of the N-methyl-d-aspartate (NMDA) receptor, and activation of nuclear factor (NF)-κB. In addition, MgD causes systemic stress response through neuroendocrinological pathways. The inflammation caused by MgD can result in pro-atherogenic changes in the metabolism of lipoproteins, endothelial dysfunction, and high blood pressure. Studies suggest that magnesium may play an important role in the pathophysiology of some inflammatory diseases. Several clinical trials and laboratory studies have been done on the functional role of magnesium. In this study, we review some inflammatory diseases, in which the magnesium has a role in their pathophysiology. Among these diseases, diabetes, asthma, preeclampsia, atherosclerosis, heart damage, and rheumatoid arthritis have been highlighted.


Magnesium Magnesium deficiency Inflammation Asthma Autoimmunity 


Compliance with ethical standards

Conflict of interest

The authors report no conflicts of interest.


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Authors and Affiliations

  1. 1.Rheumatology Research CenterTehran University of Medical SciencesTehranIran
  2. 2.Department of Immunology, School of MedicineTehran University of Medical SciencesTehranIran
  3. 3.Students’ Scientific Research CenterTehran University of Medical SciencesTehranIran
  4. 4.Department of Medical Immunology, School of MedicineFasa University of Medical SciencesFasaIran

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