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The effects of coenzyme Q10 supplementation on biomarkers of inflammation and oxidative stress in among coronary artery disease: a systematic review and meta-analysis of randomized controlled trials

  • Mohammad Vahid Jorat
  • Reza Tabrizi
  • Fariba Kolahdooz
  • Maryam Akbari
  • Maryamalsadat Salami
  • Seyed Taghi Heydari
  • Zatollah AsemiEmail author
Review Article

Abstract

Objective

Systemic inflammation and oxidative stress significantly contribute in developing coronary artery disease (CAD). This systematic review and meta-analysis was aimed to determine the effects of coenzyme Q10 (CoQ10) supplementation on biomarkers of inflammation and oxidative stress among patients with CAD.

Methods

The electronic databases including MEDLINE, EMBASE, Scopus, Web of Science, and Cochrane Library databases were systematically searched until Oct 2018. The quality assessment and heterogeneity of the selected randomized clinical Trials (RCTs) were examined using the Cochrane Collaboration risk of bias tool, and Q and I2 tests, respectively. Given the presence of heterogeneity, random-effects model or fixed-effect model were used to pool standardized mean differences (SMDs) as summary effect sizes.

Results

A total of 13 clinical RCTs of 912 potential citations were found to be eligible for the current meta-analysis. The pooled findings for biomarkers of inflammation and oxidative stress demonstrated that CoQ10 supplementation significantly increased superoxide dismutase (SOD) (SMD 2.63; 95% CI, 1.17, 4.09, P < 0.001; I2 = 94.5%) and catalase (CAT) levels (SMD 1.00; 95% CI, 0.57, 1.43, P < 0.001; I2 = 24.5%), and significantly reduced malondialdehyde (MDA) (SMD − 4.29; 95% CI − 6.72, − 1.86, P = 0.001; I2 = 97.6%) and diene levels (SMD − 2.40; 95% CI − 3.11, − 1.68, P < 0.001; I2 = 72.6%). We did not observe any significant effect of CoQ10 supplementation on C-reactive protein (CRP) (SMD − 0.62; 95% CI − 1.31, 0.08, P = 0.08; I2 = 87.9%), tumor necrosis factor alpha (TNF-α) (SMD 0.22; 95% CI − 1.07, 1.51, P = 0.73; I2 = 89.7%), interleukin-6 (IL-6) (SMD − 1.63; 95% CI − 3.43, 0.17, P = 0.07; I2 = 95.2%), and glutathione peroxidase (GPx) levels (SMD 0.14; 95% CI − 0.77, 1.04, P = 0.76; I2 = 78.7%).

Conclusions

Overall, this meta-analysis demonstrated CoQ10 supplementation increased SOD and CAT, and decreased MDA and diene levels, but did not affect CRP, TNF-α, IL-6, and GPx levels among patients with CAD.

Keywords

CoQ10 Inflammation Oxidative stress Coronary artery disease Meta-analysis 

Notes

Author contributions

ZA, MA and RT contributed in conception, design, statistical analysis and drafting of the manuscript. M-VJ, FK, MS and S-TH contributed in conception, data collection and manuscript drafting.

Funding

The research grant provided by Research Deputy of Shiraz University of Medical Sciences (SUMS).

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Mohammad Vahid Jorat
    • 1
  • Reza Tabrizi
    • 2
  • Fariba Kolahdooz
    • 3
  • Maryam Akbari
    • 2
  • Maryamalsadat Salami
    • 4
  • Seyed Taghi Heydari
    • 5
  • Zatollah Asemi
    • 6
    Email author
  1. 1.Department of CardiologyShiraz University of Medical SciencesShirazIran
  2. 2.Health Policy Research Center, Institute of Health, Student Research CommitteeShiraz University of Medical SciencesShirazIran
  3. 3.Indigenous and Global Health Research Group, Department of MedicineUniversity of AlbertaEdmontonCanada
  4. 4.Shiraz University of Medical SciencesShirazIran
  5. 5.Health Policy Research CenterInstitute of Health, Shiraz University of Medical SciencesShirazIran
  6. 6.Research Center for Biochemistry and Nutrition in Metabolic DiseasesKashan University of Medical SciencesKashanIran

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