, Volume 27, Issue 1, pp 5–13 | Cite as

Black pepper and its bioactive constituent piperine: promising therapeutic strategies for oral lichen planus

  • Jing-Ya Yang
  • Jing Zhang
  • Gang ZhouEmail author


Oral lichen planus (OLP) is a common T cell-mediated chronic inflammatory disease with malignant potential and unclear etiology. The present study suggests that antigen-specific mechanisms in which dentritic cells, T lymphocytes and NF-κB signaling pathway play critical roles, are involved in the pathogenesis of OLP. Additionally, it has been indicated that altered expression of cyclooxygenase 2 (COX-2) and imbalanced oxidant-antioxidant status as well as psychological issue may act as promoters to the development of OLP. Therapies for OLP are primarily aimed to control symptoms and a specific cure is not yet available. Black pepper and its principle bioactive compound piperine have been reported to possess remarkable pharmacological activities. Not only has piperine been evidenced to exhibit repressive effects on the maturation of dentritic cells, the proliferation, activation and function of T lymphocytes as well as the NF-κB signaling pathway, but also to suppress the overproduction of COX-2 and weaken the oxidative stress. Furthermore, piperine might be a possible agent for alleviating psychological disorders and preventing carcinogenesis. Given all these into consideration, piperine may be a novel and effective therapeutic strategy for OLP.


Black pepper Piperine Oral lichen planus 



This work was supported by grants from the National Natural Science Foundation of China (nos. 81771080, 81371147) to Gang Zhou.

Compliance with ethical standards

Conflict of interest

All authors declare no conflict of interest regarding the publication of this paper.


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© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.The State Key Laboratory Breeding Base of Basic Science of Stomatology (HubeiMOST) and Key Laboratory of Oral Biomedicine Ministry of EducationSchool and Hospital of Stomatology, Wuhan UniversityWuhanPeople’s Republic of China
  2. 2.Department of Oral MedicineSchool and Hospital of Stomatology, Wuhan UniversityWuhanPeople’s Republic of China

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