Evaluation of the effects of extracts of Maytenus imbricata (Celastraceae) on the treatment of inflammatory and metabolic dysfunction induced by high-refined carbohydrate diet
- 65 Downloads
The Maytenus genus is a member of the Celastraceae family. Numerous medicinal uses were assigned to species of this genus, with the use of roots, bark, and leaves for the treatment of gastric ulcers, as anti-inflammatory, analgesic, antiallergic, antitumor, among others. Several studies have demonstrated that natural products derived from plants have an important role in the prevention and treatment of obesity. Accordingly, we evaluated the effect of Maytenus imbricata extracts in the treatment of obesity induced by diet rich in refined carbohydrate (HC). BALB/c mice were fed chow or HC diet for 8 weeks. At the beginning of the 9th week, the HC group was subdivided into three groups: (i) group of animals that continued to consume only HC diet; (ii) the group of animals fed HC diet supplemented with ethyl acetate extract of M. imbricata roots (HC + EAE); (iii) the group of animals fed HC diet supplemented with extract in hexane/ethyl ether (HC + HEE). The period of extracts supplementation was 4 weeks. It was observed that EAE and EHE when added to the HC diet modulated the metabolic and inflammatory changes, such as: reduced the adipocytes area, improved glucose intolerance, reduced the levels of triglycerides and resistin in serum, and the number of total leukocytes in blood. In the epididymal adipose tissue, the extracts reduced proinflammatory mediators’ concentration. According to the results, it was concluded that the species Maytenus imbricata has the potential to be used for the treatment of obesity.
KeywordsMaytenus imbricata High-refined-carbohydrate diet Inflammation Metabolism Cytokines
This work was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES-Brazil) and Conselho Nacional de Pesquisa (CNPq-Brazil).
Compliance with ethical standards
Conflicts of interest
All authors declared that they have no competing interests.
- Agrawal PK (1989) Carbon-13 NMR of Flavonoids, 1st edn. New York, ElsevierGoogle Scholar
- Carvalho KM, de Melo TS, de Melo KM, Quinderé AL, de Oliveira FT, Viana AF, Nunes PI, Quetz JD, Viana DA, da Silva AA, Havt A, Fonseca SG, Chaves MH, Rao VS, Santos FA (2017) Amyrins from Protium heptaphyllum reduce high-fat diet-induced obesity in mice via modulation of enzymatic, hormonal and inflammatory responses. Planta Med 83(3–04):285–291Google Scholar
- Casaschi A, Rubio BK, Maiyoh GK, Theriault AG (2004) Inhibitory activity of diacylglycerol acyltransferase (DGAT) and microsomal triglyceride transfer protein (MTP) by the flavonoid, taxifolin, in HepG2 cells: potential role in the regulation of apolipoprotein B secretion. Atherosclerosis 176:247–253CrossRefGoogle Scholar
- Dat NT, Thao NP, Quynh LTP, Minh CV, Bach TT, Joon LJ (2009) Flavonoids from Eupatorium odoratum as inhibitors of NF-KB. JUST 47:1–6Google Scholar
- Oliveira MC, Menezes-Garcia Z, Henriques MCC, Soriani FM, Pinho V, Faria AMC et al (2013) Acute and sustained inflammation and metabolic dysfunction induced by high refined carbohydrate containing diet in mice. Obesity 21:E396–E406Google Scholar
- Veloso CC, Oliveira MC, Oliveira CC, Rodrigues VG, Giusti-Paiva A, Teixeira MM et al (2014a) Hydroethanolic extract of Pyrostegia venusta (Ker Gawl.) Miers flowers improves inflammatory and metabolic dysfunction induced by high refined carbohydrate diet. J Ethnopharmacol 151:722–728CrossRefGoogle Scholar
- Veloso CC, Rodrigues VG, Azevedo AO, Oliveira CO, Gomides LF, Duarte LP, Duarte ID, Klein A, Perez AC (2014b) Antinociceptive effects of Maytenus imbricata Mart. ex. Reissek (Celastraceae) root extract and its tingenone constituent. JMPR 8:68–76Google Scholar
- Zhou L, Li Y, Xia T, Feng S, Chen X, Yang Z (2006) Resistin overexpression impaired glucose tolerance in hepatocytes. Eur Cytokine Netw 17:189–195Google Scholar