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Inflammopharmacology

, Volume 26, Issue 4, pp 1133–1137 | Cite as

W.E.W. Roediger: Causative factors of ulcerative colitis and Crohn’s disease: an exploratory guide

Wakefield Press 2016 (reprinted 2017). 106 pp. ISBN 978 174305 433 8
  • Michael W. Whitehouse
Book Review
  • 64 Downloads

Abstract

This monograph provides the background for new developments in gastroenterological pharmacology, particularly focussing on the two chronic inflammatory bowel diseases, ulcerative colitis (UC) and Crohn’s disease (CD). These currently cause significant morbidity but largely elude satisfactory treatment. This is a challenge to drug designers and experimental physiologists alike. Their efforts will be much enhanced by further understanding the aspects of molecular pathogenesis and physiological dysregulation outlined in this valuable and timely survey.

Keywords

Crohn’s disease Ulcerative colitis Pathogenesis Nitric oxide Hydrogen sulphide Therapeutics 

Abbreviations

ATP

Adenosine-5-triphosphate

CD

Crohn’s disease

EPO

Eosinophilic peroxidase

GDS

Gut dysbiosis symptoms

GSH

Glutathione

HCN

Hydrogen cyanide

H2S

Hydrogen sulphide (or soluble salts thereof)

IBD

Inflammatory bowel diseases

NO

Nitric oxide

SCN

Thiocyanate anion

SCNO

Hypothiocyanite, the antibacterial (per)oxidation product of SCN

UC

Ulcerative colitis

Notes

Compliance with ethical standards

Conflict of interest

MWW declares no competing interests exist.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Michael W. Whitehouse
    • 1
    • 2
  1. 1.School of MedicineGriffith UniversityStones CornerAustralia
  2. 2.SouthportAustralia

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