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A Comprehensive Study of Albumin Solutions in the Extended Terahertz Frequency Range

  • M. M. Nazarov
  • O. P. Cherkasova
  • A. P. Shkurinov
Article
  • 162 Downloads

Abstract

Sensitivity of the THz frequency range to the solutions of biomolecules originates from the decrease of absorption and dispersion of water in its bound state. Correct measurement and interpretation of the THz spectra of water-containing samples is still a challenging task because the reliable relaxation model for such spectra is not well established. The transmission and the attenuated total internal reflection geometries data were combined for precise analysis of the spectra of the aqueous solutions of bovine serum albumin within the range 0.05–3.2 THz. We compare the concentration dependencies of the dielectric function at “low,” “middle,” and “high” frequency and do not confirm an anomalous increase in absorption for concentrations below 17 mg/mL published by other teams.

Keywords

Terahertz time-domain spectroscopy Transmission Attenuated total internal reflection Protein solution Water BSA Relaxation model 

Notes

Funding Information

This work has been supported by the Russian Foundation for Basic Research (project no. 17-00-00275 (17-00-00270)).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.National Research CenterKurchatov InstituteMoscowRussia
  2. 2.Institute of Laser Physics of SB RASNovosibirskRussia
  3. 3.Tomsk State UniversityTomskRussia
  4. 4.Crystallography and Photonics Federal Research CenterRussian Academy of SciencesMoskvaRussia
  5. 5.Lomonosov Moscow State UniversityMoscowRussia

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