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Inflammation

pp 1–10 | Cite as

Emodin Attenuates Severe Acute Pancreatitis via Antioxidant and Anti-inflammatory Activity

  • Shilin Xia
  • Yujia Ni
  • Qi Zhou
  • Han liu
  • Hong Xiang
  • Hua Sui
  • Dong ShangEmail author
Original Article

Abstract

There is no specific drug to treat severe acute pancreatitis (SAP), which induces substantial medical and social burden. Many studies have reported the beneficial effects of emodin against SAP in vivo and in vitro. However, the underlying mechanism has been unclear. This paper described the design and implementation of anti-inflammatory and antioxidant activity of emodin. Emodin restored the pathological damage of SAP and simultaneously decreased the high levels of serum amylase, lipase, TNF-α, and IL-18 in the peripheral blood of SAP rat. Emodin reversed reactive oxygen species (ROS) in neutrophils derived from SAP rat. The levels of voltage-dependent anion channel 1 (VDAC1), NOD-like receptor protein 3 (NLRP3), caspase-1, and IL-18 were examined to analyze the change of inflammasome-related mediators between SAP and emodin treatment. These findings suggest that emodin plays its protective role on SAP against oxidative stress and inflammasome signals.

KEY WORDS

emodin reactive oxygen species severe acute pancreatitis inflammasome signals 

Notes

Acknowledgments

We wish to acknowledge Xue Sui for the help in the flow cytometry assay and Xiaoxin Sun for the arrangement of the daily work in the laboratory.

Author Contributions

Shilin Xia and Dong Shang participated in the design of this study. Shilin Xia performed the manuscript review. Yujia Ni exerted the main experiment and performed the statistical analysis. Shilin Xia and Han Liu drafted the manuscript. Qi Zhou, Hong Xiang, and Hua Sui provided assistance for the data acquisition and data analysis. All authors read and approved the final manuscript.

Funding

This research was supported by the National Natural Science Foundation of China (No. 81873156 and No. 81703871), Key Project Supported by Clinical Ability Construction of Liaoning Province (No. LNCCC-A03-2015), and Doctoral Start-up Foundation of Liaoning Province (No. 20170520408).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Shilin Xia
    • 1
  • Yujia Ni
    • 2
  • Qi Zhou
    • 3
  • Han liu
    • 4
  • Hong Xiang
    • 1
  • Hua Sui
    • 3
  • Dong Shang
    • 3
    • 5
    Email author
  1. 1.Clinical Laboratory of Integrative MedicineThe First Affiliated Hospital of Dalian Medical UniversityDalianChina
  2. 2.Department of GeriatricsShaoxing People’s HospitalZhejiangChina
  3. 3.Institute (College) of Integrative MedicineDalian Medical UniversityDalianChina
  4. 4.Department of Oral PathologyDalian Medical UniversityDalianChina
  5. 5.Department of General SurgeryThe First Affiliated Hospital of Dalian Medical UniversityDalianChina

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