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Inflammation

, Volume 42, Issue 2, pp 463–470 | Cite as

Calgranulin B and KL-6 in Bronchoalveolar Lavage of Patients with IPF and NSIP

  • David BennettEmail author
  • Martina Salvini
  • Annalisa Fui
  • Giuseppe Cillis
  • Paolo Cameli
  • Maria Antonietta Mazzei
  • Antonella Fossi
  • Rosa Metella Refini
  • Paola Rottoli
ORIGINAL ARTICLE

Abstract

Idiopathic pulmonary fibrosis (IPF) and non-specific interstitial pneumonia (NSIP) are the most frequent idiopathic interstitial pneumonias. The aim of this study was to evaluate concentrations of calgranulin B and Krebs von den Lungen 6 (KL-6) in bronchoalveolar lavage (BAL) fluid of patients with IPF and idiopathic NSIP (i-NSIP) with fibrotic pattern. Thirty patients with IPF (68.73 ± 8.63 years), 30 with i-NSIP (68.33 ± 7.45 years), and healthy controls were included in the study. Calgranulin B and KL-6 both proved to be significantly higher in BAL of IPF and i-NSIP patients than in healthy controls (p < 0.05). Calgranulin B showed several significant correlations with functional parameters (oxygen demand at rest, 6-min walking test (6MWT), and PFTs); KL-6 was correlated with oxygen demand at rest and during 6MWT. Patients with higher concentrations of both biomarkers (> 75th percentile) had more advanced disease with lower values of FEV1%, FVC%, RV%, TLC%, DLCO% of predicted, distance walked in 6MWT, and BAL neutrophil percentage. Calgranulin B and KL-6 in BAL proved to be reliable biomarkers of IPF and i-NSIP and to have prognostic meaning, discriminating severe and advanced patients. The combination of the two biomarkers can facilitate the stratification of severity.

Key Words

biomarkers bronchoalveolar lavage calgranulin B KL-6 idiopathic pulmonary fibrosis non-specific interstitial pneumonia 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Supplementary material

10753_2018_955_MOESM1_ESM.docx (68 kb)
ESM 1 (DOCX 67 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • David Bennett
    • 1
    Email author
  • Martina Salvini
    • 1
  • Annalisa Fui
    • 1
  • Giuseppe Cillis
    • 1
  • Paolo Cameli
    • 1
  • Maria Antonietta Mazzei
    • 2
  • Antonella Fossi
    • 1
  • Rosa Metella Refini
    • 1
  • Paola Rottoli
    • 1
  1. 1.Respiratory Diseases and Lung Transplantation Unit, AOUS - Department of Medical, Surgical and Neurological SciencesUniversity of SienaSienaItaly
  2. 2.Diagnostic Imaging Unit, AOUS - Department of Medical, Surgical and Neurological SciencesUniversity of SienaSienaItaly

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