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CardioMEMS, the real progress in heart failure home monitoring

  • Edoardo GrondaEmail author
  • Emilio Vanoli
  • Alessandro Zorzi
  • Domenico Corrado
Article
  • 17 Downloads

Abstract

The burden of hospitalizations driven by exacerbation of acute heart failure remains unacceptably high. The associated use of hospital resources drives increasing patient, caregiver, and economic costs. Noninvasive telemedical systems investigated in randomized controlled trials have failed to demonstrate to reduce hospitalization rates probably because of the indirect (non-linear) relationship of the measured biological signals with the patient congestion status. Instead, there is increasing evidence that direct measure of intracardiac and pulmonary artery pressure can effectively guide heart failure management and reduce hospitalizations. Early studies adopting implantable hemodynamic monitors in the right heart unveiled the potential of pressure-based heart failure management, whereas subsequent investigations showed the powerful preemptive approach for heart failure exacerbations. One large randomized trial (CHAMPION) proved that a direct pulmonary pressure monitor system (CardioMEMS) substantially reduced heart failure hospitalizations in subjects randomized to active pulmonary pressure-guided management. The system monitoring safety and efficacy were also excellent. The study proved that early management in response to increased pulmonary pressure is able to provide the most effective therapeutic intervention to prevent heart failure exacerbations.

Keywords

Heart failure Hemodynamics Monitoring Treatment Sympathetic system Clinical studies 

Notes

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico di Milano UOC di Nefrologia, Dialisi e Trapianto Renale dell’adulto Dipartimento Di Medicina e Specialità MedicheMilanItaly
  2. 2.Department of Molecular MedicineUniversity of PaviaPaviaItaly
  3. 3.Cardiovascular DepartmentIRCCS MultiMedicaMilanItaly
  4. 4.Department of Cardiac Thoracic, Vascular Sciences and Public HealthUniversity of PadovaPadovaItaly

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