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The metabolic syndrome in heart failure: insights to specific mechanisms

  • Paola Gargiulo
  • Fabio Marsico
  • Francesco Renga
  • Simona Dell’Aversana
  • Immacolata Esposito
  • Caterina Marciano
  • Santo Dellegrottaglie
  • Pasquale Perrone-FilardiEmail author
  • Stefania Paolillo
Article
  • 28 Downloads

Abstract

The presence of comorbidities significantly influences long-term morbidity and mortality of symptomatic and asymptomatic heart failure (HF) patients. Metabolic syndrome and diabetic cardiomyopathy are two clinical conditions that share multiple pathophysiological mechanisms and that might be both responsible for cardiac dysfunction. However, it is argued whether metabolic syndrome (MS) independently increases HF risk or the association between MS and HF merely reflects the impact of individual risk factors included in its definition on HF development. Similarly, in the context of diabetic cardiomyopathy, many aspects are still challenging starting from the definition up to the therapeutic management. In this clinical review, we focused the attention on molecular pathways, myocyte alterations, and specific patterns of metabolic syndrome and diabetic cardiomyopathy in order to better define the potential diagnostic and therapeutic approaches of these two pathological conditions.

Keywords

Heart failure Metabolic syndrome Diabetic cardiomyopathy Insulin resistance 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Paola Gargiulo
    • 1
  • Fabio Marsico
    • 2
  • Francesco Renga
    • 2
  • Simona Dell’Aversana
    • 2
  • Immacolata Esposito
    • 2
  • Caterina Marciano
    • 3
  • Santo Dellegrottaglie
    • 4
  • Pasquale Perrone-Filardi
    • 2
    Email author
  • Stefania Paolillo
    • 2
    • 5
  1. 1.IRCCS SDNNaplesItaly
  2. 2.Department of Advanced Biomedical Sciences, Section of CardiologyFederico II University of NaplesNaplesItaly
  3. 3.Istituto Diagnostico VarelliNaplesItaly
  4. 4.Division of CardiologyOspedale Accreditato Villa dei FioriAcerraItaly
  5. 5.Mediterranea CardiocentroNaplesItaly

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