Heart Failure Reviews

, Volume 24, Issue 4, pp 473–480 | Cite as

Personalized physiology-guided resuscitation in highly monitored patients with cardiac arrest—the PERSEUS resuscitation protocol

  • Athanasios ChalkiasEmail author
  • Eleni Arnaoutoglou
  • Theodoros Xanthos


Resuscitation guidelines remain uniform across all cardiac arrest patients, focusing on the delivery of chest compressions to a standardized rate and depth and algorithmic vasopressor dosing. However, individualizing resuscitation to the appropriate hemodynamic and ventilatory goals rather than a standard “one-size-fits-all” treatment seems a promising new therapeutic strategy. In this article, we present a new physiology-guided treatment strategy to titrate the resuscitation efforts to patient’s physiologic response after cardiac arrest. This approach can be applied during resuscitation attempts in highly monitored patients, such as those in the operating room or the intensive care unit, and could serve as a method for improving tissue perfusion and oxygenation while decreasing post-resuscitation adverse effects.


Resuscitation Physiology-guided treatment Pathophysiology Cardiac arrest Monitoring 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Authors and Affiliations

  1. 1.Faculty of Medicine, Department of AnesthesiologyUniversity of ThessalyLarisaGreece
  2. 2.Hellenic Society of Cardiopulmonary ResuscitationAthensGreece
  3. 3.Department of AnesthesiologyUniversity Hospital of LarisaLarisaGreece
  4. 4.School of MedicineEuropean University CyprusNicosiaCyprus

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