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Heart Failure Reviews

, Volume 24, Issue 4, pp 461–472 | Cite as

READY: relative efficacy of loop diuretics in patients with chronic systolic heart failure—a systematic review and network meta-analysis of randomised trials

  • Tobias Täger
  • Hanna Fröhlich
  • Mirjam Seiz
  • Hugo A. Katus
  • Lutz FrankensteinEmail author
Article

Abstract

The majority of patients with chronic heart failure (HF) receive long-term treatment with loop diuretics. The comparative effectiveness of different loop diuretics is unknown. We searched PubMed, clinicaltrials.gov, the Cochrane Central Register of Controlled Trials and the European Union Clinical Trials Register for randomised clinical trials exploring the efficacy of the loop diuretics azosemide, bumetanide, furosemide or torasemide in patients with HF. Comparators included placebo, standard medical care or any other active treatment. The primary endpoint was all-cause mortality. Secondary endpoints included cardiovascular mortality, HF-related hospitalisation and any combined endpoint thereof. Hypokalaemia and acute renal failure were defined as additional safety endpoints. Evidence was synthesised using network meta-analysis (NMA). Thirty-four trials reporting on 2647 patients were included. The overall quality of evidence was rated as moderate. NMA demonstrated no significant differences between loop diuretics with respect to all-cause mortality, cardiovascular mortality or hypokalaemia. In contrast, torasemide ranked best in terms of HF hospitalisation, and there was a trend towards benefits with torasemide with regard to occurrence of acute renal failure. Sensitivity analyses excluding trials with a follow-up < 6 months, trials with a cross-over design and those including < 25 patients confirmed the main results. We found no significant superiority of either loop diuretic with respect to mortality and safety endpoints. However, clinicians may prefer torasemide, as it was associated with fewer HF-related hospitalisations.

Keywords

Heart failure Loop diuretics Mortality Prognosis Network meta-analysis 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Disclosure

Tobias Täger has nothing to disclose. Hanna Fröhlich has nothing to disclose. Mirjam Seiz has nothing to disclose. H.A. Katus has nothing to disclose. L. Frankenstein has nothing to disclose.

Supplementary material

10741_2019_9771_MOESM1_ESM.pdf (310 kb)
ESM 1 (PDF 309 kb)
10741_2019_9771_MOESM2_ESM.pdf (433 kb)
ESM 2 (PDF 433 kb)

References

  1. 1.
    Adams KF Jr, Fonarow GC, Emerman CL, LeJemtel TH, Costanzo MR, Abraham WT, Berkowitz RL, Galvao M, Horton DP (2005) Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE). Am Heart J 149:209–216CrossRefGoogle Scholar
  2. 2.
    Ahmed A, Husain A, Love TE, Gambassi G, Dell'Italia LJ, Francis GS, Gheorghiade M, Allman RM, Meleth S, Bourge RC (2006) Heart failure, chronic diuretic use, and increase in mortality and hospitalization: an observational study using propensity score methods. Eur Heart J 27:1431–1439CrossRefGoogle Scholar
  3. 3.
    Allman S, Norris RJ (1990) An open, parallel group study comparing a frusemide/amiloride diuretic and a diuretic containing cyclopenthiazide with sustained release potassium in the treatment of congestive cardiac failure--a multicentre general practice study. J Int Med Res 18(Suppl 2):17b–23bGoogle Scholar
  4. 4.
    Asami M, Aoki J, Tanimoto S, Horiuchi Y, Watanabe M, Furui K, Yasuhara K, Sato T, Tanabe K, Hara K (2017) Effects of long-acting loop diuretics in heart failure with reduced ejection fraction patients with cardiac resynchronization therapy. Int Heart J 58:211–219CrossRefGoogle Scholar
  5. 5.
    Bikdeli B, Strait KM, Dharmarajan K, Partovian C, Coca SG, Kim N, Li SX, Testani JM, Khan U, Krumholz HM (2013) Dominance of furosemide for loop diuretic therapy in heart failure: time to revisit the alternatives? J Am Coll Cardiol 61:1549–1550CrossRefGoogle Scholar
  6. 6.
    Bleske BE, Welage LS, Kramer WG, Nicklas JM (1998) Pharmacokinetics of torsemide in patients with decompensated and compensated congestive heart failure. J Clin Pharmacol 38:708–714CrossRefGoogle Scholar
  7. 7.
    Buggey J, Mentz RJ, Pitt B, Eisenstein EL, Anstrom KJ, Velazquez EJ, O'Connor CM (2015) A reappraisal of loop diuretic choice in heart failure patients. Am Heart J 169:323–333CrossRefGoogle Scholar
  8. 8.
    Chaimani A, Higgins JP, Mavridis D et al (2013) Graphical tools for network meta-analysis in STATA. PLoS One 8:e76654CrossRefGoogle Scholar
  9. 9.
    Chaudhury RR, Chugh KS, Gupta GS et al (1968) A controlled clinical trial comparing the diuretic furosemide and hydrochlorothiazide. J Assoc Physicians India 16:157–163Google Scholar
  10. 10.
    Cody RJ, Franklin KW, Laragh JH (1982) Postural hypotension during tilt with chronic captopril and diuretic therapy of severe congestive heart failure. Am Heart J 103:480–484CrossRefGoogle Scholar
  11. 11.
    Cosin J, Diez J, Investigators T (2002) Torasemide in chronic heart failure: results of the TORIC study. Eur J Heart Fail 4:507–513CrossRefGoogle Scholar
  12. 12.
    Crawford RJ, Allman S, Gibson W, Kitchen S, Richards HH (1988) A comparative study of frusemide-amiloride and cyclopenthiazide-potassium chloride in the treatment of congestive cardiac failure in general practice. J Int Med Res 16:143–149CrossRefGoogle Scholar
  13. 13.
    Damman K, Kjekshus J, Wikstrand J, Cleland JGF, Komajda M, Wedel H, Waagstein F, McMurray JJV (2016) Loop diuretics, renal function and clinical outcome in patients with heart failure and reduced ejection fraction. Eur J Heart Fail 18:328–336CrossRefGoogle Scholar
  14. 14.
    Dini FL, Ghio S, Klersy C, Rossi A, Simioniuc A, Scelsi L, Genta FT, Cicoira M, Tavazzi L, Temporelli PL (2013) Effects on survival of loop diuretic dosing in ambulatory patients with chronic heart failure using a propensity score analysis. Int J Clin Pract 67:656–664CrossRefGoogle Scholar
  15. 15.
    Dinicolantonio JJ (2012) Should torsemide be the loop diuretic of choice in systolic heart failure? Futur Cardiol 8:707–728CrossRefGoogle Scholar
  16. 16.
    Domanski M, Norman J, Pitt B, Haigney M, Hanlon S, Peyster E, Studies of Left Ventricular Dysfunction (2003) Diuretic use, progressive heart failure, and death in patients in the Studies Of Left Ventricular Dysfunction (SOLVD). J Am Coll Cardiol 42:705–708CrossRefGoogle Scholar
  17. 17.
    Faris RF, Flather M, Purcell H et al (2012) Diuretics for heart failure. Cochrane Database Syst Rev:CD003838Google Scholar
  18. 18.
    Ferrara N, Leosco D, Del P et al (1997) Torasemide versus furosemide in patients with congestive heart failure: a double-masked, randomized study. Curr Ther Res Clin Exp:291–299Google Scholar
  19. 19.
    Funke Kupper AJ, Fintelman H, Huige MC et al (1986) Cross-over comparison of the fixed combination of hydrochlorothiazide and triamterene and the free combination of furosemide and triamterene in the maintenance treatment of congestive heart failure. Eur J Clin Pharmacol 30:341–343CrossRefGoogle Scholar
  20. 20.
    Gabriel R, Baylor P (1981) Comparison of the chronic effects of bendrofluazide, bumetanide and frusemide on plasma biochemical variables. Postgrad Med J 57:71–74CrossRefGoogle Scholar
  21. 21.
    Goebel KM (1993) Six-week study of torsemide in patients with congestive heart failure. Clin Ther 15:1051–1059Google Scholar
  22. 22.
    Group. TTI (2011) Effects of prolonged-release torasemide versus furosemide on myocardial fibrosis in hypertensive patients with chronic heart failure: a randomized, blinded-end point, active-controlled study. Clin Ther 33:1204–1213.e1203CrossRefGoogle Scholar
  23. 23.
    Gupta S, Waywell C, Gandhi N, Clayton N, Keevil B, Clark AL, Ng LL, Brooks N, Neyses L (2010) The effects of adding torasemide to standard therapy on peak oxygen consumption, natriuretic peptides, and quality of life in patients with compensated left ventricular systolic dysfunction. Eur J Heart Fail 12:746–752CrossRefGoogle Scholar
  24. 24.
    Hall SA, Cigarroa CG, Marcoux L, Risser RC, Grayburn PA, Eichhorn EJ (1995) Time course of improvement in left ventricular function, mass and geometry in patients with congestive heart failure treated with beta-adrenergic blockade. J Am Coll Cardiol 25:1154–1161CrossRefGoogle Scholar
  25. 25.
    Hamaguchi S, Kinugawa S, Tsuchihashi-Makaya M, Goto D, Yamada S, Yokoshiki H, Takeshita A, Tsutsui H, The JCARE-CARD Investigators (2012) Loop diuretic use at discharge is associated with adverse outcomes in hospitalized patients with heart failure: a report from the Japanese cardiac registry of heart failure in cardiology (JCARE-CARD). Circ J 76:1920–1927CrossRefGoogle Scholar
  26. 26.
    Han LN, Guo SL, Lin XM, Shi XM, Zang CB, Yang LM, Ding GL (2014) Torasemide reduces dilated cardiomyopathy, complication of arrhythmia, and progression to heart failure. Genet Mol Res 13:7262–7274CrossRefGoogle Scholar
  27. 27.
    Harada K, Izawa H, Nishizawa T, Hirashiki A, Murase Y, Kobayashi M, Isobe S, Cheng XW, Noda A, Nagata K, Yokota M, Murohara T (2009) Beneficial effects of torasemide on systolic wall stress and sympathetic nervous activity in asymptomatic or mildly symptomatic patients with heart failure: comparison with azosemide. J Cardiovasc Pharmacol 53:468–473CrossRefGoogle Scholar
  28. 28.
    Higgins J, Green S, (Editors) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. In:The Cochrane Collaboration, 2011Google Scholar
  29. 29.
    Higgins JP, Jackson D, Barrett JK et al (2012) Consistency and inconsistency in network meta-analysis: concepts and models for multi-arm studies. Res Synth Methods 3:98–110CrossRefGoogle Scholar
  30. 30.
    Hisatake S, Nanjo S, Fujimoto S, Yamashina S, Yuzawa H, Namiki A, Nakano H, Yamazaki J (2011) Comparative analysis of the therapeutic effects of long-acting and short-acting loop diuretics in the treatment of chronic heart failure using (123)I-metaiodobenzylguanidine scintigraphy. Eur J Heart Fail 13:892–898CrossRefGoogle Scholar
  31. 31.
    Hussain M, Walton K, Davidson C, Morgan DB (1985) A study of two diuretic/potassium combinations in heart failure. Postgrad Med J 61:29–33CrossRefGoogle Scholar
  32. 32.
    Hutton B, Catala-Lopez F, Moher D (2016) The PRISMA statement extension for systematic reviews incorporating network meta-analysis: PRISMA-NMA. Med Clin 147:262–266CrossRefGoogle Scholar
  33. 33.
    Jansen JP, Trikalinos T, Cappelleri JC, Daw J, Andes S, Eldessouki R, Salanti G (2014) Indirect treatment comparison/network meta-analysis study questionnaire to assess relevance and credibility to inform health care decision making: an ISPOR-AMCP-NPC Good Practice Task Force report. Value Health 17:157–173CrossRefGoogle Scholar
  34. 34.
    Kasama S, Toyama T, Hatori T, Sumino H, Kumakura H, Takayama Y, Ichikawa S, Suzuki T, Kurabayashi M (2006) Effects of torasemide on cardiac sympathetic nerve activity and left ventricular remodelling in patients with congestive heart failure. Heart 92:1434–1440CrossRefGoogle Scholar
  35. 35.
    Komajda M, Follath F, Swedberg K, Cleland J, Aguilar JC, Cohen-Solal A, Dietz R, Gavazzi A, van Gilst W, Hobbs R, Korewicki J, Madeira HC, Moiseyev VS, Preda I, Widimsky J, Freemantle N, Eastaugh J, Mason J, Study Group on Diagnosis of the Working Group on Heart Failure of the European Society of Cardiology (2003) The EuroHeart Failure Survey programme--a survey on the quality of care among patients with heart failure in Europe. Part 2: treatment. Eur Heart J 24:464–474CrossRefGoogle Scholar
  36. 36.
    Konecke LL (1981) Clinical trial of bumetanide versus furosemide in patients with congestive heart failure. J Clin Pharmacol 21:688–690CrossRefGoogle Scholar
  37. 37.
    Kremer D (1983) Treatment of cardiac failure with diuretics. A double-blind study comparing a fixed combination of hydrochlorothiazide/amiloride and furosemide plus potassium substitution. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 103:1165–1168Google Scholar
  38. 38.
    Levy B (1977) The efficacy and safety of furosemide and a combination of spironolactone and hydrochlorothiazide in congestive heart failure. J Clin Pharmacol 17:420–430CrossRefGoogle Scholar
  39. 39.
    Lopes JA, Jorge S (2013) The RIFLE and AKIN classifications for acute kidney injury: a critical and comprehensive review. Clin Kidney J 6:8–14CrossRefGoogle Scholar
  40. 40.
    Lopez B, Querejeta R, Gonzalez A et al (2004) Effects of loop diuretics on myocardial fibrosis and collagen type I turnover in chronic heart failure. J Am Coll Cardiol 43:2028–2035CrossRefGoogle Scholar
  41. 41.
    Lopez B, Gonzalez A, Beaumont J et al (2007) Identification of a potential cardiac antifibrotic mechanism of torasemide in patients with chronic heart failure. J Am Coll Cardiol 50:859–867CrossRefGoogle Scholar
  42. 42.
    Mareev V, Mareev Y, Vygodin V et al (2017) Mortality and rehospitalization data from diuretic therapy with effective doses of oral torasemide and furosemide in treatment of patients with exacerbation of chronic heart failure (DUEL-CHF) trial. In: European journal of heart failure. Conference: heart failure 2016 and the 3rd world congress on acute heart failure. Florence Italy. Conference start: 20160521. Conference end: 20160524. Conference publication: (var.pagings). P 382-383Google Scholar
  43. 43.
    Masuyama T, Tsujino T, Origasa H, Yamamoto K, Akasaka T, Hirano Y, Ohte N, Daimon T, Nakatani S, Ito H (2012) Superiority of long-acting to short-acting loop diuretics in the treatment of congestive heart failure. Circ J 76:833–842CrossRefGoogle Scholar
  44. 44.
    Matsuo Y, Kasama S, Toyama T, Funada R, Takama N, Koitabashi N, Ichikawa S, Suzuki Y, Matsumoto N, Sato Y, Kurabayashi M (2016) Comparative effects of long-acting and short-acting loop diuretics on cardiac sympathetic nerve activity in patients with chronic heart failure. Open Heart 3:e000276CrossRefGoogle Scholar
  45. 45.
    Mauersberger H, Rangoonwala B, Ehrlich E (1985) Comparative study of 2 diuretic-containing combination preparations in patients with edematous heart failure. Wien Med Wochenschr (1946) 135:205–213Google Scholar
  46. 46.
    Mentz RJ, Velazquez EJ, Metra M, McKendry C, Chiswell K, Fiuzat M, Givertz MM, Voors AA, Teerlink JR, O'Connor CM (2015) Comparative effectiveness of torsemide versus furosemide in heart failure patients: insights from the PROTECT trial. Futur Cardiol 11:585–595CrossRefGoogle Scholar
  47. 47.
    Mentz RJ, Hasselblad V, Devore AD et al (2016) Torsemide versus furosemide in patients with acute heart failure (from the ASCEND-HF Trial). Am J Cardiol 117:404–411CrossRefGoogle Scholar
  48. 48.
    Miyata M, Sasaki T, Ikeda Y, Shinsato T, Kubozono T, Furusho Y, Kusumoto A, Hamasaki S, Tei C, COLD-CHF Investigators (2012) Comparative study of therapeutic effects of short- and long-acting loop diuretics in outpatients with chronic heart failure (COLD-CHF). J Cardiol 59:352–358CrossRefGoogle Scholar
  49. 49.
    Moher D, Shamseer L, Clarke M et al (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev 4:1CrossRefGoogle Scholar
  50. 50.
    Moher D, Stewart L, Shekelle P (2016) Implementing PRISMA-P: recommendations for prospective authors. Syst Rev 5:15CrossRefGoogle Scholar
  51. 51.
    Muller K, Gamba G, Jaquet F et al (2003) Torasemide vs. furosemide in primary care patients with chronic heart failure NYHA II to IV--efficacy and quality of life. Eur J Heart Fail 5:793–801CrossRefGoogle Scholar
  52. 52.
    Murray MD, Deer MM, Ferguson JA, Dexter PR, Bennett SJ, Perkins SM, Smith FE, Lane KA, Adams LD, Tierney WM, Brater DC (2001) Open-label randomized trial of torsemide compared with furosemide therapy for patients with heart failure. Am J Med 111:513–520CrossRefGoogle Scholar
  53. 53.
    Noe LL, Vreeland MG, Pezzella SM, Trotter JP (1999) A pharmacoeconomic assessment of torsemide and furosemide in the treatment of patients with congestive heart failure. Clin Ther 21:854–866CrossRefGoogle Scholar
  54. 54.
    Ogino K, Kinugasa Y, Kato M, Yamamoto K, Hisatome I, Anker SD, Doehner W (2014) Spironolactone, not furosemide, improved insulin resistance in patients with chronic heart failure. Int J Cardiol 171:398–403CrossRefGoogle Scholar
  55. 55.
    Packer M, Medina N, Yushak M, Meller J (1983) Hemodynamic patterns of response during long-term captopril therapy for severe chronic heart failure. Circulation 68:803–812CrossRefGoogle Scholar
  56. 56.
    Packer M, Lee WH, Medina N, Yushak M, Kessler PD (1987) Functional renal insufficiency during long-term therapy with captopril and enalapril in severe chronic heart failure. Ann Intern Med 106:346–354CrossRefGoogle Scholar
  57. 57.
    Parker JO (1993) The effects of oral ibopamine in patients with mild heart failure--a double blind placebo controlled comparison to furosemide. The Ibopamine Study Group. Int J Cardiol 40:221–227CrossRefGoogle Scholar
  58. 58.
    Pehrsson SK (1985) Multicentre comparison between slow-release furosemide and bendroflumethiazide in congestive heart failure. Eur J Clin Pharmacol 28:235–239CrossRefGoogle Scholar
  59. 59.
    Pellicori P, Cleland JG, Zhang J et al (2016) Cardiac dysfunction, congestion and loop diuretics: their relationship to prognosis in heart failure. Cardiovasc Drugs Ther 30:599–609CrossRefGoogle Scholar
  60. 60.
    Pitt B, Zannad F, Remme WJ et al (1999) The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 341:709–717CrossRefGoogle Scholar
  61. 61.
    Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, Falk V, González-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GMC, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P, ESC Scientific Document Group (2016) 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 37:2129–2200CrossRefGoogle Scholar
  62. 62.
    Puhan MA, Schunemann HJ, Murad MH, Li T, Brignardello-Petersen R, Singh JA, Kessels AG, Guyatt GH, for the GRADE Working Group (2014) A GRADE Working Group approach for rating the quality of treatment effect estimates from network meta-analysis. BMJ 349:g5630CrossRefGoogle Scholar
  63. 63.
    Ramsay F, Crawford RJ, Allman S, Bailey R, Martin A (1988) An open comparative study of two diuretic combinations, frusemide/amiloride (‘Frumil’) and bumetanide/potassium chloride (‘Burinex’ K), in the treatment of congestive cardiac failure in hospital out-patients. Curr Med Res Opin 10:682–689CrossRefGoogle Scholar
  64. 64.
    Salanti G (2012) Indirect and mixed-treatment comparison, network, or multiple-treatments meta-analysis: many names, many benefits, many concerns for the next generation evidence synthesis tool. Res Synth Methods 3:80–97CrossRefGoogle Scholar
  65. 65.
    Salanti G, Marinho V, Higgins JP (2009) A case study of multiple-treatments meta-analysis demonstrates that covariates should be considered. J Clin Epidemiol 62:857–864CrossRefGoogle Scholar
  66. 66.
    Salanti G, Ades AE, Ioannidis JP (2011) Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial. J Clin Epidemiol 64:163–171CrossRefGoogle Scholar
  67. 67.
    Salanti G, Del Giovane C, Chaimani A et al (2014) Evaluating the quality of evidence from a network meta-analysis. PLoS One 9:e99682CrossRefGoogle Scholar
  68. 68.
    Sargento L, Simoes AV, Longo S et al (2016) Furosemide prescription during the dry state is a predictor of long-term survival of stable, optimally medicated patients with systolic heart failure. J Cardiovasc Pharmacol TherGoogle Scholar
  69. 69.
    Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA, the PRISMA-P Group (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ 349:g7647CrossRefGoogle Scholar
  70. 70.
    Sharpe N, Murphy J, Smith H et al (1988) Treatment of patients with symptomless left ventricular dysfunction after myocardial infarction. Lancet (London, England) 1:255–259CrossRefGoogle Scholar
  71. 71.
    Stewart JH, Edwards KD (1965) Clinical comparison of frusemide with bendrofluazide, mersalyl, and ethacrynic acid. Br Med J 2:1277–1281CrossRefGoogle Scholar
  72. 72.
    Torafic Investigators Group (2011) Effects of prolonged-release torasemide versus furosemide on myocardial fibrosis in hypertensive patients with chronic heart failure: a randomized, blinded-end point, active-controlled study. Clin Ther 33(1204–1213):e1203Google Scholar
  73. 73.
    Tsutamoto T, Sakai H, Wada A, Ishikawa C, Ohno K, Fujii M, Yamamoto T, Takayama T, Dohke T, Horie M (2004) Torasemide inhibits transcardiac extraction of aldosterone in patients with congestive heart failure. J Am Coll Cardiol 44:2252–2253CrossRefGoogle Scholar
  74. 74.
    Uchida T, Yamanaga K, Nishikawa M, Ohtaki Y, Kido H, Watanabe M (1991) Anti-aldosteronergic effect of torasemide. Eur J Pharmacol 205:145–150CrossRefGoogle Scholar
  75. 75.
    Van Kraaij DJ, Jansen RW, Bouwels LH et al (1999) Furosemide withdrawal improves postprandial hypotension in elderly patients with heart failure and preserved left ventricular systolic function. Arch Intern Med 159:1599–1605CrossRefGoogle Scholar
  76. 76.
    Vargo DL, Kramer WG, Black PK, Smith WB, Serpas T, Brater DC (1995) Bioavailability, pharmacokinetics, and pharmacodynamics of torsemide and furosemide in patients with congestive heart failure. Clin Pharmacol Ther 57:601–609CrossRefGoogle Scholar
  77. 77.
    Veeraveedu PT, Watanabe K, Ma M, Palaniyandi SS, Yamaguchi K’, Suzuki K, Kodama M, Aizawa Y (2008) Torasemide, a long-acting loop diuretic, reduces the progression of myocarditis to dilated cardiomyopathy. Eur J Pharmacol 581:121–131CrossRefGoogle Scholar
  78. 78.
    Veeraveedu PT, Watanabe K, Ma M, Thandavarayan RA, Palaniyandi SS, Yamaguchi K’, Suzuki K, Kodama M, Aizawa Y (2008) Comparative effects of torasemide and furosemide in rats with heart failure. Biochem Pharmacol 75:649–659CrossRefGoogle Scholar
  79. 79.
    Vermeulen A, Chadha DR (1982) Slow-release furosemide and hydrochlorothiazide in congestive cardiac failure: a controlled trial. J Clin Pharmacol 22:513–519CrossRefGoogle Scholar
  80. 80.
    Watanabe K, Sreedhar R, Thandavarayan RA et al (2016) Comparative effects of torasemide and furosemide on gap junction proteins and cardiac fibrosis in a rat model of dilated cardiomyopathy. BiofactorsGoogle Scholar
  81. 81.
    Westheim AS, Bostrom P, Christensen CC et al (1999) Hemodynamic and neuroendocrine effects for candoxatril and frusemide in mild stable chronic heart failure. J Am Coll Cardiol 34:1794–1801CrossRefGoogle Scholar
  82. 82.
    Wilson JR, Reichek N, Dunkman WB, Goldberg S (1981) Effect of diuresis on the performance of the failing left ventricle in man. Am J Med 70:234–239CrossRefGoogle Scholar
  83. 83.
    Yamato M, Sasaki T, Honda K, Fukuda M, Akutagawa O, Okamoto M, Hayashi T (2003) Effects of torasemide on left ventricular function and neurohumoral factors in patients with chronic heart failure. Circ J 67:384–390CrossRefGoogle Scholar

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Authors and Affiliations

  1. 1.Department of Cardiology, Angiology, and PulmonologyUniversity Hospital HeidelbergHeidelbergGermany

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