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Heart Failure Reviews

, Volume 24, Issue 1, pp 133–142 | Cite as

Cell-based therapies for the treatment of myocardial infarction: lessons from cardiac regeneration and repair mechanisms in non-human vertebrates

  • Paul Palmquist-Gomes
  • José María Pérez-Pomares
  • Juan Antonio GuadixEmail author
Article
  • 226 Downloads

Abstract

Ischemic cardiomyopathy is the cardiovascular condition with the highest impact on the Western population. In mammals (humans included), prolonged ischemia in the ventricular walls causes the death of cardiomyocytes (myocardial infarction, MI). The loss of myocardial mass is soon compensated by the formation of a reparative, non-contractile fibrotic scar that ultimately affects heart performance. Despite the enormous clinical relevance of MI, no effective therapy is available for the long-term treatment of this condition. Moreover, since the human heart is not able to undergo spontaneous regeneration, many researchers aim at designing cell-based therapies that allow for the substitution of dead cardiomyocytes by new, functional ones. So far, the majority of such strategies rely on the injection of different progenitor/stem cells to the infarcted heart. These cardiovascular progenitors, which are expected to differentiate into cardiomyocytes de novo, seldom give rise to new cardiac muscle. In this context, the most important challenge in the field is to fully disclose the molecular and cellular mechanisms that could promote active myocardial regeneration after cardiac damage. Accordingly, we suggest that such strategy should be inspired by the unique regenerative and reparative responses displayed by non-human animal models, from the restricted postnatal myocardial regeneration abilities of the murine heart to the full ventricular regeneration of some bony fishes (e.g., zebrafish). In this review article, we will discuss about current scientific approaches to study cardiac reparative and regenerative phenomena using animal models.

Keywords

Myocardial infarction Cell-based therapies Tissue regeneration Tissue repair Animal models 

Notes

Acknowledgements

We thank all present and past members of our laboratory for fruitful discussions.

Funding

This work was supported by the Spanish Ministry of Economy (MINECO) [grant number BFU2015-65783-R] and [grant number SAF2015-71863] (to JMPP); Instituto de Salud Carlos III (MINECO-ISCIII) [grant number RD16/0011/0030-TERCEL] (to JMPP); Plan Propio-Universidad de Málaga (to JAG); Spanish Society of Cardiology grant, “Proyectos de la SEC para Investigación Básica en Cardiología 2018” (to JAG).

Compliance with ethical standards

Conflict of interests

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Paul Palmquist-Gomes
    • 1
    • 2
  • José María Pérez-Pomares
    • 1
    • 2
  • Juan Antonio Guadix
    • 1
    • 2
    Email author
  1. 1.Department of Animal Biology, Faculty of SciencesUniversity of Málaga, Instituto Malagueño de Biomedicina (IBIMA)MálagaSpain
  2. 2.BIONAND, Centro Andaluz de Nanomedicina y Biotecnología (Junta de Andalucía, Universidad de Málaga)MálagaSpain

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