Heart Failure Reviews

, Volume 24, Issue 1, pp 101–108 | Cite as

Autonomic nervous system in Takotsubo syndrome

  • Sonia Borodzicz
  • Katarzyna Czarzasta
  • Grzegorz Opolski
  • Agnieszka Cudnoch-JędrzejewskaEmail author


Takotsubo syndrome (TTS) is an acute and usually reversible heart failure syndrome with symptoms resembling acute myocardial infarction, however, without obstruction of coronary arteries. In the majority of cases, TTS is preceded by emotional or physical stress and the disease concerns mainly postmenopausal women. Although several hypotheses have been introduced, the pathogenesis of TTS is controversial and still remains to be determined. As reported in recent studies, the role of the autonomic nervous system (ANS) seems to be pivotal in the pathogenesis of TTS. Therefore, the aim of this article is to summarize and discuss the current knowledge of the pathogenesis of TTS with a special focus on the ANS.


Takotsubo syndrome Pathophysiology Autonomic nervous system Sympathetic nervous system 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standards

The manuscript does not contain clinical studies or patient data.


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Authors and Affiliations

  1. 1.Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical ResearchMedical University of WarsawWarsawPoland
  2. 2.1st Chair and Department of CardiologyMedical University of WarsawWarsawPoland

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