Role of AGEs in the progression and regression of atherosclerotic plaques
The formation of advanced glycation end-products(AGEs) is an important cause of metabolic memory in diabetic patients and a key factor in the formation of atherosclerosis(AS) plaques in patients with diabetes mellitus. Related studies showed that AGEs could disrupt hemodynamic steady-state and destroy vascular wall integrity through the endothelial barrier damage, foam cell(FC) formation, apoptosis, calcium deposition and other aspects. At the same time, AGEs could initiate oxidative stress and inflammatory response cascade via receptor-depended and non-receptor-dependent pathways, promoting plaques to develop from a steady state to a vulnerable state and eventually tend to rupture and thrombosis. Numerous studies have confirmed that these pathological processes mentioned above could lead to acute coronary heart disease(CHD) and other acute cardiovascular and cerebrovascular events. However, the specific role of AGEs in the progression and regression of AS plaques has not yet been fully elucidated. In this paper, the formation, source, metabolism, physical and chemical properties of AGEs and their role in the migration of FCs and plaque calcification are briefly described, we hope to provide new ideas for the researchers that struggling in this field.
KeywordsAdvanced glycation end-products Foam cell migration Plaque calcification Atherosclerosis
advanced glycation end-products
coronary heart disease
vascular smooth muscle cell
Availability of data and materials
All authors contributed to conception and design and wrote the review; All authors read and approved the final manuscript.
This work was supported by the National Natural Science Foundation of China (Grant Nos. 81770450, 81370408, 81670105); Jiangsu Provincial Health and Family Planning Commission project(QNRC2016836); the Open Program of Key Laboratory of Nuclear Medicine, Ministry of Health and Jiangsu Key Laboratory of Molecular Nuclear Medicine(KF201504); Innovation plan for postgraduate research in Jiangsu Province(KYCX17_1801).
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Conflicts of interest
The authors declare that they have no competing interests.
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