Glass and Ceramics

, Volume 76, Issue 1–2, pp 77–81 | Cite as

Properties of Composites with Calcium Phosphate Filled Polymer Matrix, Obtained Using Stereolithographic Printing for Ceramic Materials with Prescribed Pore-Space Architecture

  • S. A. TikhonovaEmail author
  • P. V. Evdokimov
  • T. V. Safronova
  • V. I. Putlyaev

The process of removing an organic component from composites (photopolymer/calcium phosphate) with complex architecture, which are obtained by 3D-printing in order to create personalized bioceramic implants, was studied. Ceramic materials with complex pore-space organization were obtained by stereolithographic printing. It is shown that the degree of polymerization of the composite influences the final density of the calcium phosphate ceramic materials with complex architecture.

Key words

bioceramic tricalcium phosphate additive technologies 3D printing stereolithography osteoconductivity sintering 


This work was performed under RSF Grant No. 14-19-00752-P.

The results used in this work were obtained on equipment acquired under the program of development of Moscow University.


  1. 1.
    S. M. Barinov and V. S. Komlev, Bioceramics Based on Calcium Phosphates [in Russian], Nauka, Moscow (2005).Google Scholar
  2. 2.
    R. Agarwal and A. J. Garcia, “Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair,” Adv. Drug Delivery Rev., 94, 53 – 62 (2015).CrossRefGoogle Scholar
  3. 3.
    C. Liu, “Collagen-hydroxyapatite composite scaffolds for tissue engineering,” in: Woodhead Publishing Series in Biomaterials, V. Hydroxyapatite (Hap) for Biomedical Applications (2015), pp. 211 – 234.Google Scholar
  4. 4.
    V. I. Putlyaev, “Modern bioceramic materials,” Sorovskii Obrazovatel’nyi Zh., 8, No. 1 (2004).Google Scholar
  5. 5.
    V. M. Ievlev, V. I. Putlyaev, T. V. Safronova, and P. V. Evdokimov, “Additive technologies for making highly permeable inorganic materials with tailored morphological architectonics for medicine,” Inorg. Mater., 51(13), 1297 – 1315 (2015).CrossRefGoogle Scholar
  6. 6.
    M. Bohner and J. Lemaitre, “Can bioactivity be tested in vitro with SBF solution?,” Biomaterials, 30(12), 2175 – 2179 (2009).CrossRefGoogle Scholar
  7. 7.
    M. Bohner, “Calcium orthophosphates in medicine: from ceramics to calcium phosphate cements,” Biomaterials, 31(4), 457 – 459 (2000).Google Scholar
  8. 8.
    M. Canillas, P. Pena, A. H. De Aza, and M. A. Rodriguez, “Calcium phosphates for biomedical applications,” Boletin de La Sociedad Espanola de Ceramica y Vidrio, 56(3), 91 – 112 (2017).CrossRefGoogle Scholar
  9. 9.
    T. Albrektsson, and C. Johansson, “Osteoinduction, osteoconduction and osseointegration,” Europ. Spine J., 10, 96 – 101 (2001).CrossRefGoogle Scholar
  10. 10.
    K. A. Hing, “Bioceramic bone graft substitutes: influence of porosity and chemistry,” Int. J. Appl. Ceram. Technol., 2(3), 184 – 199 (2005).CrossRefGoogle Scholar
  11. 11.
    P. Habibovic, U. Gbureck, C. J. Doillon, et al., “Osteoconduction and osteoinduction of low-temperature 3D printed bioceramic implants,” Biomaterials, 29(7), 944 – 953 (2008).CrossRefGoogle Scholar
  12. 12.
    A. A. Tikhonov, P. V. Evdokimov, V. I. Putlyaev, et al., “On the choice of the architecture of osteoconductive bioceramic implants,” Materialovedenie, No. 8, 43 – 48 (2018).Google Scholar
  13. 13.
    J. W. Halloran, “Ceramic stereolithography: additive manufacturing for ceramics by photopolymerization,” Annual Rev. Mater. Res., 46(1), 19 – 40 (2016).CrossRefGoogle Scholar
  14. 14.
    C. Mota, D. Puppi, F. Chiellini, and E. Chiellini, “Additive manufacturing techniques for the production of tissue engineering constructs,” J. Tissue Eng. Regen. Med., 9(3), 174 – 190 (2012).CrossRefGoogle Scholar
  15. 15.
    J.-B. Lee, W.-Y. Maeng, Y.-H. Koh, and H.-E. Kim, “Porous calcium phosphate ceramic scaffolds with tailored pore orientations and mechanical properties using lithography-based ceramic 3D printing technique,” Materials, 11(9), 711 (2018).Google Scholar
  16. 16.
    Matthew Conrad, Experimental Investigations and Theoretical Modeling of Large area Maskless Photopolymerization with Grayscale Exposure, Georgia Institute of Technology (2011).Google Scholar
  17. 17.
    V. I. Putlyaev, P. V. Evdokimov, T. V. Safronova, et al., “Fabrication of osteoconductive Ca3–xM2x(PO4)2 (M = Na, K) calcium phosphate bioceramics by stereolithographic 3D printing,” Inorg. Mater., 53(5), 529 – 535 (2017).CrossRefGoogle Scholar
  18. 18.
    P. F. Jacobs and D. T. Reid, Rapid Prototyping & Manufacturing: Fundamentals of Stereolithography, Society of Manufacturing Engineers in cooperation with the Computer and Automated Systems Association of SME (1992).Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • S. A. Tikhonova
    • 1
    Email author
  • P. V. Evdokimov
    • 1
  • T. V. Safronova
    • 1
  • V. I. Putlyaev
    • 1
  1. 1.M. V. Lomonosov Moscow State UniversityMoscowRussia

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