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Nanoporous Glass with Controlled Pore Size for High-Efficiency Synthesis of Oligonucleotides

  • G. Yu. Shakhgil’dyanEmail author
  • K. I. Piyanzina
  • A. A. Stepko
  • A. N. Natyrov
  • A. M. Mikhailov
  • V. I. Savinkov
  • V. N. Sigaev
SCIENCE FOR GLASS PRODUCTION
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The results of work on the development of powder nanoporous glass (NPG) with controlled pore size for solid-phase synthesis of oligonucleotides with heightened product yield are presented. NPG with a narrow pore-size distribution was obtained by varying the parameters of the heat and chemical treatment of sodium-borosilicate glasses. It was found that the functional charge of the material is equal to 72 μmol/g. It is shown that using the developed NPG in the synthesis of long-chain oligonucleotides increases the product yield more than seven-fold compared with the analogous material offered on the market.

Key words

nanoporous glass alkali-borosilicate glass glass with controlled pore size CPG synthesis of oligonucleotides 

Notes

This work was supported by the Ministry of Education and Science of the Russian Federation (contract No. 14.Z50.31.0009).

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • G. Yu. Shakhgil’dyan
    • 1
    Email author
  • K. I. Piyanzina
    • 1
  • A. A. Stepko
    • 1
  • A. N. Natyrov
    • 2
  • A. M. Mikhailov
    • 1
  • V. I. Savinkov
    • 1
  • V. N. Sigaev
    • 1
  1. 1.D. I. Mendeleev University of Chemical Technology of RussiaMoscowRussia
  2. 2.Scientific and Industrial Firm Sintol, JSCMoscowRussia

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