Nanoporous Glass with Controlled Pore Size for High-Efficiency Synthesis of Oligonucleotides
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The results of work on the development of powder nanoporous glass (NPG) with controlled pore size for solid-phase synthesis of oligonucleotides with heightened product yield are presented. NPG with a narrow pore-size distribution was obtained by varying the parameters of the heat and chemical treatment of sodium-borosilicate glasses. It was found that the functional charge of the material is equal to 72 μmol/g. It is shown that using the developed NPG in the synthesis of long-chain oligonucleotides increases the product yield more than seven-fold compared with the analogous material offered on the market.
Key wordsnanoporous glass alkali-borosilicate glass glass with controlled pore size CPG synthesis of oligonucleotides
This work was supported by the Ministry of Education and Science of the Russian Federation (contract No. 14.Z50.31.0009).
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