Familial Cancer

, Volume 18, Issue 2, pp 267–271 | Cite as

Progress report on the major clinical advances in patient-oriented research into familial melanoma (2013–2018)

  • Mijke Visser
  • Nienke van der Stoep
  • Nelleke GruisEmail author


Over 200,000 melanoma cases are diagnosed each year worldwide, leading to 55,000 deaths [1], and in most countries the annual incidence of melanoma is still increasing. Once melanoma has metastasised, it rapidly becomes life-threatening [1], underlining the importance of earlier diagnosis and better prevention. Melanoma aetiology is complex and heterogeneous, and environmental/lifestyle, phenotypic and genetic susceptibility contribute to melanoma genesis in a multifactorial manner [2]. UV radiation is known to be a major environmental risk factor, with a direct mutagenic role in melanoma pathogenesis [2, 3]. Phenotypic risk factors include light pigmentation, tendency to sunburn, inability to tan, and a large number of melanocytic nevi [2, 4].

While 90% of all melanoma cases are sporadic, 10% occur in a familial setting, defined by at least two first-degree relatives affected with melanoma [5]. Genetic susceptibility can be explained by the inheritance of either low,...



MV was supported by a grant from the Dutch Cancer Society (Grant No. UL2012-5489).


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of DermatologyLeiden University Medical CenterLeidenThe Netherlands
  2. 2.Department of Clinical GeneticsLeiden University Medical CenterLeidenThe Netherlands

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