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Simultaneous determination of drug active compound, hormones, pesticides, and endocrine disruptor compounds in wastewater samples by GC-MS with direct calibration and matrix matching strategies after preconcentration with dispersive liquid-liquid microextraction

  • Elif Seda Koçoğlu
  • Onur Sözüdoğru
  • Okan Tarık KomesliEmail author
  • Alper Erdem Yılmaz
  • Sezgin BakırdereEmail author
Article
  • 97 Downloads

Abstract

DLLME was coupled with GC-MS for the simultaneous determination of a drug active compound, hormones, pesticides, and endocrine disruptor compounds with high accuracy and reproducibility in this study. Extraction parameters that affect extraction output including types and volumes of dispersive and extraction solvents, and effect of salt addition were optimized to lower the detection limits for 12 compounds. Under the optimum conditions, LOD and LOQ values were found between 1.99–5.05 and 6.63–16.87 ng/mL, respectively. Spiked recovery tests were also applied to wastewater samples to check the applicability of the method. Matrix matching strategy was used to improve the overall recovery results of the analytes obtained for municipal wastewater. Two different municipal wastewater samples were used in the matrix matching studies. Percent recovery values calculated with the matrix matching experiments were between 85–114%. The results obtained indicated that the developed method could be applied for the determination of the analytes of interest with high accuracy and sensitivity.

Keywords

DLLME Drug active compounds Endocrine disruptors GC-MS Hormones Pesticides 

Abbreviations

EDC

Endocrine disruptor compound

DLLME

Dispersive liquid-liquid microextraction

RSD

Relative standard deviation

LOD

Limit of detection

LOQ

Limit of quantification

GC-MS

Gas chromatography-mass spectrometry

NPD

Nitrogen-phosphorus detector

FID

Flame ionization detector

MSD

Mass spectrometric detector

DAD

Diode array detector

BPA-D16

Deuterated bisphenol A

Notes

Funding information

This work was supported by the Scientific and Technological Research Council of Turkey (Tubitak) (Scientific Research Project, Project Number 115Y576).

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Elif Seda Koçoğlu
    • 1
  • Onur Sözüdoğru
    • 2
  • Okan Tarık Komesli
    • 2
    Email author
  • Alper Erdem Yılmaz
    • 2
  • Sezgin Bakırdere
    • 1
    Email author
  1. 1.Department of ChemistryYildiz Technical UniversityİstanbulTurkey
  2. 2.Department of Environmental EngineeringAtatürk UniversityErzurumTurkey

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