Comparison of the occurrence of antibiotic residues in two rural ponds: implication for ecopharmacovigilance
- 134 Downloads
As a well-accepted drug-administration strategy for the minimization of environmental risks posed by pharmaceutical residues, ecopharmacovigilance (EPV) needs to guard against and control the pharmaceutical pollution sources. However, the underlying routes by which pharmaceuticals reach the environment vary significantly under different scenes, so it is necessary to implement different EPV measures in different backgrounds. This study detected the occurrence of antibiotic residues in two ponds within a Chinese rural community; assessed their ecological risks; compared and analyzed the geographic and demographic information, as well as the antibiotic-related anthropogenic behaviors of residents living around ponds, in order to trace the main entrances of antibiotics into the water environment; and then propose the EPV measures according to rural conditions. The results showed that the pollution degree of antibiotic residues was different between two studied ponds, which was manifested by the different antibiotic types and levels in water samples. And the possible main sources of antibiotic pollution in the studied rural water environment might include the application of human excretions and animal manures as fertilizers on the farmland, antibiotic use and inappropriate disposal in the clinic, and the direct disposal of the leftover antibiotics. From the perspective of drug administration, we then identified some suggestions on EPV measures which could be taken under existing rural conditions, including encouraging eco-directed sustainable prescribing of antibiotics in human and animals, improving take-back collection of unused antibiotics, building monitoring mechanism for antibiotic residues in the natural environment, identifying high-priority antibiotic residues, and implementing targeted EPV.
KeywordsWater environment Pharmaceuticals Antibacterial drug administration Rural area Ecopharmacovigilance measures
Funding of the study came from the National Natural Science Foundation of China (No. 81602108), Humanities and Social Science Foundation from Hubei Province Ministry of Education (No. 16Y023), Research Program of Hubei Provincial Department of Education (No. B2017012), and Research Program of Hubei Province Key Laboratory of Occupational Hazard Identification and Control (Nos. OHIC2017G07 and OHIC2017G05).
Compliance with ethical standards
Conflicts of interest
The authors declare that they have no conflict of interest.
- González-Pleiter, M., Gonzalo, S., Rodea-Palomares, I., Leganés, F., Rosal, R., Boltes, K., Marco, E., & Fernández-Piñas, F. (2013). Toxicity of five antibiotics and their mixtures towards photosynthetic aquatic organisms: Implications for environmental risk assessment. Water Research, 47(6), 2050–2064.CrossRefGoogle Scholar
- Gros, M., Rodríguez-Mozaz, S., & Barceló, D. (2013). Rapid analysis of multiclass antibiotic residues and some of their metabolites in hospital, urban wastewater and river water by ultra-high-performance liquid chromatography coupled to quadrupole-linear ion trap tandem mass spectrometry. Journal of Chromatography A, 1292, 173–188.CrossRefGoogle Scholar
- Hanna, N., Sun, P., Sun, Q., Li, X., Yang, X., Ji, X., et al. (2018). Presence of antibiotic residues in various environmental compartments of Shandong province in eastern China: Its potential for resistance development and ecological and human risk. Environment International, 114, 131–142.Google Scholar
- Kim, C., Ryu, H. D., Chung, E. G., & Kim, Y. (2018). Determination of 18 veterinary antibiotics in environmental water using high-performance liquid chromatography-q-orbitrap combined with on-line solid-phase extraction. Journal of Chromatography B-Analytical technologies in the Biomedical and Life Science, 1084, 158–165.CrossRefGoogle Scholar
- Lien, L. T., Hoa, N. Q., Chuc, N. T., Thoa, N. T., Phuc, H. D., Diwan, V., et al. (2016). Antibiotics in wastewater of a rural and an Urban Hospital before and after wastewater treatment, and the relationship with antibiotic use-a one year study from Vietnam. Journal of environmental research and. Public Health, 13(6).CrossRefGoogle Scholar
- Limbu, S. M., Zhou, L., Sun, S. X., Zhang, M. L., & Du, Z. Y. (2018). Chronic exposure to low environmental concentrations and legal aquaculture doses of antibiotics cause systemic adverse effects in Nile tilapia and provoke differential human health risk. Environment International, 115, 205–219.Google Scholar
- Liu, J. L., & Wong, M. H. (2013). Pharmaceuticals and personal care products (PPCPs): A review on environmental contamination in China. Environment International, 59, 208–224.Google Scholar
- Łukaszewicz, P., Maszkowska, J., Mulkiewicz, E., Kumirska, J., Stepnowski, P., & Caban, M. (2017). Impact of veterinary pharmaceuticals on the agricultural environment: A re-inspection. Reviews of Environmental Contamination and Toxicology, 243, 89–148.Google Scholar
- Wang, J., He, B., Yan, D., & Hu, X. (2017). Implementing ecopharmacovigilance (EPV) from a pharmacy perspective: A focus on non-steroidal anti-inflammatory drugs. Science of the Total environment. In 603–604,772–784.Google Scholar