European Journal of Epidemiology

, Volume 34, Issue 10, pp 917–926 | Cite as

Green tea consumption and mortality in Japanese men and women: a pooled analysis of eight population-based cohort studies in Japan

  • Sarah Krull Abe
  • Eiko Saito
  • Norie Sawada
  • Shoichiro Tsugane
  • Hidemi Ito
  • Yingsong Lin
  • Akiko Tamakoshi
  • Junya Sado
  • Yuri Kitamura
  • Yumi Sugawara
  • Ichiro Tsuji
  • Chisato Nagata
  • Atsuko Sadakane
  • Taichi Shimazu
  • Tetsuya Mizoue
  • Keitaro Matsuo
  • Mariko Naito
  • Keitaro Tanaka
  • Manami InoueEmail author
  • Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan


The aim of our study was to assess the association between green tea consumption and all-cause and cause-specific mortality in a pooled analysis of eight Japanese population-based cohort studies. Pooled hazard ratios (HR) and 95% confidence intervals (CI), derived from random effects models, were used to evaluate the associations between green tea consumption, based on self-report at baseline, and risk of all-cause and cause-specific mortality. During a mean follow-up of 17.3 years, among 313,381 persons, 52,943 deaths occurred. Compared with individuals who consumed < 1 cup/day, those in the highest consumption category (≥ 5 cups/day) had a decreased risk of all-cause mortality [the multivariate-adjusted HR was 0.90 (95% CI 0.87–0.94) for men and 0.82 (0.74–0.90) for women]. A similar inverse association was observed for heart disease mortality [HR 0.82 (0.75–0.90) for men, and 0.75 (0.68–0.84) for women], and cerebrovascular disease mortality [HR 0.76 (0.68–0.85) for men, and 0.78 (0.68–0.89) for women]. Among women, green tea consumption was associated with decreased risk of total cancer mortality: 0.89 (0.83–0.96) for the 1–2 cups/day category and 0.91 (0.85–0.98) for the 3–4 cups/day category. Results for respiratory disease mortality were [HR 0.75 (0.61–0.94)] among 3–4 cup daily consumers and [HR 0.66 (0.55–0.79)] for ≥ 5 cups/day. Higher consumption of green tea is associated with lower risk for all-cause mortality in Japanese, especially for heart and cerebrovascular disease. Moderate consumption decreased the risk of total cancer and respiratory disease mortality in women.


Green tea Mortality Cohort study Pooled analysis Japan 



The Japan Public Health Center-based Prospective Study, Cohort I


The Japan Public Health Center-based Prospective Study, Cohort II


The Japan Collaborative Cohort Study


The Miyagi Cohort Study


The Ohsaki National Health Insurance Cohort Study

3-pref MIYAGI

The Three Prefecture Study—Miyagi portion

3-pref AICHI

The Three Prefecture Study—Aichi portion

3-pref OSAKA

The Three Prefecture Study—Osaka portion


Author’s contribution

MI designed the research. SKA performed the analyses, prepared the tables and drafted the paper. MI, ES, NS, ST, YL, and AS supported analyses, discussions and finalizing of the paper. HI, YL, AT, JS, YK, YS, IT, CN, TS, TM, KM, MN, and KT provided valuable feedback regarding interpretation of the results. All authors read and approved the final manuscript.


This study was supported by the National Cancer Center Research and Development Funds (30-A-15, 27-A-4, 24-A-3) and the Health and Labour Sciences Research Grants for the Third Term Comprehensive Control Research for Cancer (H21-3jigan-ippan-003, H18-3jigan-ippan-001, H16-3jigan-010). The funders had no role in the design, data collection, analysis, interpretation or manuscript drafting, or in the decision to submit the manuscript for publication.

Compliance with ethical standards

Conflict of interest

The authors have no potential conflicts of interests.

Supplementary material

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Sarah Krull Abe
    • 1
  • Eiko Saito
    • 2
  • Norie Sawada
    • 1
  • Shoichiro Tsugane
    • 1
  • Hidemi Ito
    • 3
    • 4
  • Yingsong Lin
    • 5
  • Akiko Tamakoshi
    • 6
  • Junya Sado
    • 7
  • Yuri Kitamura
    • 7
  • Yumi Sugawara
    • 8
  • Ichiro Tsuji
    • 8
  • Chisato Nagata
    • 9
  • Atsuko Sadakane
    • 10
  • Taichi Shimazu
    • 1
  • Tetsuya Mizoue
    • 11
  • Keitaro Matsuo
    • 4
    • 12
  • Mariko Naito
    • 13
  • Keitaro Tanaka
    • 14
  • Manami Inoue
    • 1
    • 15
    Email author
  • Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan
  1. 1.Epidemiology and Prevention Group, Center for Public Health SciencesNational Cancer CenterTokyoJapan
  2. 2.Division of Cancer Statistics and Integration, Center for Cancer Control and Information ServicesNational Cancer CenterTokyoJapan
  3. 3.Division of Cancer Information and ControlAichi Cancer Center Research InstituteNagoyaJapan
  4. 4.Department of EpidemiologyNagoya University Graduate School of MedicineNagoyaJapan
  5. 5.Department of Public HealthAichi Medical University School of MedicineNagakuteJapan
  6. 6.Department of Public HealthHokkaido University Graduate School of MedicineSapporoJapan
  7. 7.Division of Environmental Medicine and Population Sciences, Department of Social and Environmental Medicine, Graduate School of MedicineOsaka UniversitySuitaJapan
  8. 8.Division of Epidemiology, Department of Public Health and Forensic MedicineTohoku University Graduate School of MedicineSendaiJapan
  9. 9.Department of Epidemiology and Preventive MedicineGifu University Graduate School of MedicineGifuJapan
  10. 10.Department of EpidemiologyRadiation Effects Research FoundationHiroshimaJapan
  11. 11.Department of Epidemiology and Prevention, Center for Clinical SciencesNational Center for Global Health and MedicineTokyoJapan
  12. 12.Division of Cancer Epidemiology and PreventionAichi Cancer Center Research InstituteNagoyaJapan
  13. 13.Department of Oral Epidemiology, Graduate School of Biomedical and Health SciencesHiroshima UniversityHiroshimaJapan
  14. 14.Department of Preventive Medicine, Faculty of MedicineSaga UniversitySagaJapan
  15. 15.Department of Cancer Epidemiology, Graduate School of MedicineThe University of TokyoTokyoJapan

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