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Contribution of the OC Sensor® immunoassay in comparison to the Hemoccult II® guaiac-test in organized colorectal cancer screening

  • Carole Vitellius
  • Margot Laly
  • Anne-Sophie Banaszuk
  • Isabelle Deherce
  • Nathanaëlle Cornet
  • Sandrine Bertrais
  • Patrick Saulnier
  • François-Xavier Caroli-Bosc
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Abstract

Colorectal cancer (CRC) is a major cause of cancer-related death of worldwide with high incidence and mortality rate, accessible to a screening program in France, first with guaiac- based fecal occult blood test (g-FOBT) then with fecal immunochemical tests (FIT), since 2015, because of better accuracy. The aim of our study was to compare the characteristics of screen-detected lesions in two successive CRC screening campaigns, using two different tests (Hemoccult II® and OC Sensor®) in the department of Maine-et-Loire, and to precise the performance of these tests [participation rate, detection rates (DR), positive predictive value (PPV)]. Participants, invited by CAP SANTE 49, with polyps or cancer at the colonoscopy after a positive screening test between 01/01/2013 and 31/12/2016 were included. A guaiac-based fecal occult blood test (g-FOBT) was used from January 2013 to December 2014 and a FIT was used from June 2015 to December 2016). 2575 participants, 642 in g-FOBT group and 1933 in FIT group had lesions. Participation rate was not different between tests (p = 0.104), whereas DR and PPV were statistically higher in FIT for all lesions (2.61, 95% CI [2.50–2.70] vs 0.93, 95% CI [0.90–1.00], p < 0.0001 and 64.84, 95% CI [63.10–66.60], 50.00, 95% CI [47.30–52.70], p < 0.0001 respectively). FIT detects more precancerous lesions (adenomas, p < 0.001, and advanced adenomas, p < 0.001) than g-FOBT but g-FOBT detects more serrated polyps (p = 0.025). AAs were more in right colon in FIT than g-FOBT (p = 0.035). No different participation rate was detected between FIT and g-FOBT but DR and PPV of all lesions was higher with FIT.

Keywords

Colorectal cancer Screening Immunochemical test Performance test 

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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  • Carole Vitellius
    • 1
    • 2
  • Margot Laly
    • 1
  • Anne-Sophie Banaszuk
    • 2
  • Isabelle Deherce
    • 2
  • Nathanaëlle Cornet
    • 1
  • Sandrine Bertrais
    • 2
  • Patrick Saulnier
    • 4
  • François-Xavier Caroli-Bosc
    • 1
    • 2
    • 3
  1. 1.Service d’Hépato-gastro-entérologieCHU AngersAngers Cedex 09France
  2. 2.HIFIH Laboratory, UNIV AngersUniversité Bretagne LoireAngersFrance
  3. 3.CAP-Santé 49AngersFrance
  4. 4.MINT Laboratory, UNIV Angers, INSERM 1066, CNRS 6021Université Bretagne LoireAngersFrance

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