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European Journal of Epidemiology

, Volume 34, Issue 3, pp 259–265 | Cite as

Cancer incidence among Finnish people with type 2 diabetes during 1989–2014

  • Katri SaarelaEmail author
  • Jaakko Tuomilehto
  • Reijo Sund
  • Ilmo Keskimäki
  • Sirpa Hartikainen
  • Eero Pukkala
DIABETES MELLITUS

Abstract

Diabetes and cancer are common diseases both with enormous impact on health burden globally. The increased risk of several types of cancer among people with type 2 diabetes mellitus has been indicated repeatedly. This study aimed at exploring and describing the association between type 2 diabetes and cancer incidence. A cohort of 428,326 people with type 2 diabetes was identified from the Finnish National Diabetes Register and followed up through a register linkage with the Finnish Cancer Registry for cancer incidence during 1988–2014. A total of 74,063 cases of cancer occurred in this cohort in 4.48 million person-years. This accounted for 16% more than the expected cancer incidence in the Finnish general population; the standardized incidence ratio (SIR) was 1.16 (95% confidence interval [CI] 1.15–1.16). There was a statistically significant excess of cancers of lip (SIR = 1.40, CI = 1.28–1.53), liver (SIR = 2.44, CI = 2.35–2.53), pancreas (SIR = 1.75, CI = 1.70–1.79), stomach (SIR = 1.22, CI = 1.18–1.26), colon (SIR = 1.22, CI = 1.19–1.25), gallbladder and bile ducts (SIR = 1.29, CI = 1.21–1.36), non-melanoma skin (SIR = 1.18, CI = 1.15–1.22), kidney (SIR = 1.42, CI = 1.37–1.47), bladder (SIR = 1.17, CI = 1.13–1.21), and thyroid (SIR = 1.22, CI = 1.12–1.31). There was a small statistically significant decrease in prostate cancer incidence (SIR = 0.95, CI = 0.93–0.96). This study showed an association between type 2 diabetes mellitus and the incidence of cancer at numerous sites in the Finnish population.

Keywords

Diabetes Cohort study Record linkage Cancer 

Notes

Acknowledgements

This study has been partly supported by the research Grants to JT from the Finnish Cancer Foundation, European Foundation for the Study of Diabetes and Sanofi-Aventis. JT is an advisory board member of Novo Nordisk and Merck KGaA. SH has received lecture fees from MSD.

Compliance with ethical standards

Conflict of interest

Authors KS, RS, IK and EP declare that they have no conflict of interest.

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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Chronic Disease Prevention UnitNational Institute for Health and WelfareHelsinkiFinland
  2. 2.Department of Public HealthUniversity of HelsinkiHelsinkiFinland
  3. 3.Dasman Diabetes InstituteDasmanKuwait
  4. 4.Diabetes Research GroupKing Abdulaziz UniversityJeddahSaudi Arabia
  5. 5.Department of Social ResearchUniversity of HelsinkiHelsinkiFinland
  6. 6.Institute of Clinical MedicineUniversity of Eastern FinlandKuopioFinland
  7. 7.Faculty of Social SciencesUniversity of TampereTampereFinland
  8. 8.Department of Health and Social Care SystemsNational Institute for Health and WelfareHelsinkiFinland
  9. 9.School of PharmacyUniversity of Eastern FinlandKuopioFinland
  10. 10.Finnish Cancer RegistryInstitute for Statistical and Epidemiological Cancer ResearchHelsinkiFinland

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