Vision loss and 12-year risk of dementia in older adults: the 3C cohort study
- 53 Downloads
To analyze the longitudinal relationships between vision loss and the risk of dementia in the first 2 years, from 2 to 4 years and beyond 4 years after inclusion and to determine the roles of depressive symptomatology and engagement in cognitively stimulating activities in these associations. This study is based on the Three-City (3C) study, a population-based cohort of 7736 initially dementia-free participants aged 65 years and over with 12 years of follow-up. Near visual impairment (VI) was measured and distance visual function (VF) loss was self-reported. Dementia was diagnosed and screened over the 12-year period. At baseline, 8.7% had mild near VI, 4.2% had moderate to severe near VI, and 5.3% had distance VF loss. Among the 882 dementia cases diagnosed over the 12-year follow-up period, 140 cases occurred in the first 2 years, 149 from 2 to 4 years and 593 beyond 4 years after inclusion. In Cox multivariate analysis, moderate to severe near VI was associated with an increased risk of dementia in the first 2 years (HR 2.0, 95% CI 1.2–3.3) and from 2 to 4 years (HR 1.8, 95% CI 1.1–3.1) but the association was not significant beyond 4 years after inclusion even if pointing in similar direction (HR 1.3, 95% CI 0.95–1.9). Mild near VI was associated with an increased risk of dementia only in the first 2 years (HR 1.6, 95% CI 1.1–2.5). Moreover, self-reported distance VF loss was associated with an increased risk beyond 4 years after inclusion (HR 1.5, 95% CI 1.1–2.0) but the association was no longer significant after taking into account baseline cognitive performances. Further adjustment for engagement in cognitively stimulating activities only slightly decreased these associations. However, there was an interaction between vision loss and depressive symptomatology, with vision loss associated with dementia only among participants with depressive symptomatology. These results suggest that poor vision, in particular near vision loss, may represent an indicator of dementia risk at short and middle-term, mostly in depressed elderly people.
KeywordsVision loss Dementia Cohort study Epidemiology
Study funding: The Three-City study is conducted under a partnership agreement between the Institut National de la Santé et de la Recherche Médicale (INSERM), the University Bordeaux 2 Victor Segalen and Sanofi-Aventis. The Fondation pour la Recherche Médicale funded the preparation and initiation of the study. The Three-City study is also supported by the Caisse Nationale Maladie des Travailleurs Salariés, Direction Générale de la Santé, MGEN, Institut de la Longévité, Conseils Régionaux d’Aquitaine et Bourgogne, Fondation de France, Ministry of Research-INSERM Programme “Cohortes et collections de données biologiques”, Agence Nationale de la Recherche ANR PNRA 2006 and LongVie 2007, the “Fondation Plan Alzheimer” (FCS 2009-2012) and the Caisse Nationale de Solidarité pour l’Autonomie (CNSA). None of the sponsors participated in the collection, management, statistical analysis and interpretation of the data, nor in the preparation, review or approval of the present manuscript. SENSE-Cog has received funding from the European Union’s Horizon 2020 research and innovation program under Grant agreement No. 668648.
List of Sense-Cog Consortium: Geir Bertelsen1,2, Suzanne Cosh3, Audrey Cougnard-Grégoire3, Piers Dawes4, Cécile Delcourt3, Fofi Constantinidou5, Catherine Helmer3, M. Arfan Ikram 6,7, Caroline CW Klaver 6,8, Iracema Leroi 9, Asri Maharani 9,10, Magda Meester-Smor 6,8, Unal Mutlu 6,8, Virginie Nael3,11,12, Neil Pendleton 9,10, Henrik Schirmer 13, Gindo Tampubolon 14, Henning Tiemeier 6,15, Therese von Hanno 16,17.
1: UiT The Arctic University of Norway, Department of Community Medicine, Faculty of Health Sciences, N-9037 Tromsø, Norway
2: University Hospital of North Norway, Department of Ophthalmology, N-9038 Tromsø, Norway
3: Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, team LEHA, UMR 1219, F-33000 Bordeaux, France
4: University of Manchester, Manchester Centre for Audiology and Deafness, School of Health Sciences, Manchester, UK
5: University of Cyprus, Department of Psychology & Center for Applied Neuroscience, Nicosia, Cyprus
6: Erasmus Medical Centre, Department of Epidemiology, Rotterdam, The Netherlands
7: Erasmus Medical Centre, Departments of Neurology and Radiology, Rotterdam, The Netherlands
8: Erasmus Medical Centre, Department of Ophthalmology, Rotterdam, The Netherlands
9: University of Manchester, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Manchester, UK
10: University of Manchester, Academic Health Science Centre, Manchester, UK
11: Sorbonne University, UMPC University of Paris 06, INSERM, CNRS, Vision Institute, F-75012 Paris, France
12: R&D Life and Vision Science, Essilor International, F-75012 Paris, France
13: UiT-The Arctic University of Norway, Department of Clinical Medicine, Cardiovascular research Group-UNN, N-9037 Tromsø, Norway
14: University of Manchester, Global Development Institute, Manchester, UK
15: Erasmus Medical Centre, Department of Psychiatry, Rotterdam, The Netherlands
16: UiT-The Arctic University of Norway, Department of Clinical Medicine, Faculty of Health Sciences, N-9037 Tromsø, Norway
17: Nordland Hospital, Department of Ophthalmology, N-8092 Bodø, Norway
Compliance with ethical standards
Conflict of interest
Authors V. Naël and AC Scherlen are Essilor International employees. Author C. Delcourt is a consultant for Bausch & Lomb, Novartis, and Laboratoires Théa and has received research grants from Laboratoires Théa. The authors K. Pérès, JF. Dartigues, L. Letenneur, H. Amieva, A. Arleo, I. Carrière, C. Tzourio, C. Berr and C. Helmer declare that they have no conflict of interest.
Research involving human participants
All procedures performed in studies involving human participants were in accordance with the ethical standards of the Kremlin-Bicêtre University Hospital and Sud-Mediterranée III committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- 5.Garin N, Olaya B, Lara E, Moneta MV, Miret M, Ayuso-Mateos JL, et al. Visual impairment and multimorbidity in a representative sample of the Spanish population. BMC Public Health. 2014;14.Google Scholar
- 9.de Kok DS, Teh RO, Pillai A, Connolly MJ, Wilkinson TJ, Moyes SA, et al. What is the relationship between visual impairment and cognitive function in octogenarians? N Z Med J. 2017;130:33–47.Google Scholar
- 11.Hong T, Mitchell P, Burlutsky G, Liew G, Wang JJ. Visual impairment, hearing loss and cognitive function in an older population: longitudinal findings from the Blue Mountains Eye Study. PLoS ONE. 2016;11.Google Scholar
- 26.Tsai S-Y, Cheng C-Y, Hsu W-M, Su T-PT, Liu J-H, Chou P. Association between visual impairment and depression in the elderly. J Formos Med Assoc Taiwan Yi Zhi. 2003;102:86–90.Google Scholar
- 33.Benton A. Manuel pour l’application du test de retention visuelle. Applications cliniques et expérimentales. Deuxième édition française. Paris: Centre de Psychologie Appliquée; 1965.Google Scholar
- 34.American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-IV. Washington DC: American Psychiatric Association; 1994.Google Scholar
- 36.Foubert-Samier A, Catheline G, Amieva H, Dilharreguy B, Helmer C, Allard M, et al. Education, occupation, leisure activities, and brain reserve: a population-based study. Neurobiol Aging. 2012;33(423):e15–25.Google Scholar
- 39.Fuhrer R, Rouillon F. La version française de l’échelle CES-D (Center for epidemiologic studies-depression scale). Description et traduction de l’échelle d’autoévaluation. Psychiatr Psychobiol. 1989;4:163–6.Google Scholar
- 40.Lin FR, Metter EJ, O’Brien RJ, Resnick SM, Zonderman AB, Ferrucci L. Hearing loss and incident dementia. Arch Neurol. 2011;68:214–20.Google Scholar
- 41.Schafer JL. Multiple imputation: a primer: Stat Methods Med Res [Internet]. 2016 [cited 2018 Oct 26]; Available from: http://journals.sagepub.com/doi/metrics/10.1177/096228029900800102.
- 42.Bowen M, Edgar DF, Hancock B, Haque S, Shah R, Buchanan S, et al. The prevalence of visual impairment in people with dementia (the PrOVIDe study). Southampton: NIHR Journals Library; 2016.Google Scholar
- 44.Cosh S, Carrière I, Daien V, Tzourio C, Delcourt C, Helmer C. Sensory loss and suicide ideation in older adults: findings from the Three-City cohort study. Int Psychogeriatr. 2018;1–7.Google Scholar
- 45.Baker ML, Wang JJ, Rogers S, Klein R, Kuller LH, Larsen EK, et al. Early age-related macular degeneration, cognitive function, and dementia: the Cardiovascular Health Study. Arch Ophthalmol Chic Ill. 1960;2009(127):667–73.Google Scholar
- 46.Naël V, Moreau G, Monfermé S, Cougnard-Grégoire A, Scherlen A-C, Arleo A, et al. Prevalence and associated factors of uncorrected refractive error in older adults in a population-based study in France. JAMA Ophthalmol. 2018.Google Scholar