Investigational New Drugs

, Volume 37, Issue 4, pp 763–770 | Cite as

Efficacy and safety of lanreotide in Korean patients with metastatic, well-differentiated gastroenteropancreatic-neuroendocrine tumors: a retrospective analysis

  • Junho Kang
  • Changhoon YooEmail author
  • Hee-Sang Hwang
  • Seung-Mo Hong
  • Kyu-pyo Kim
  • Sun Young Kim
  • Yong-Sang Hong
  • Tae Won Kim
  • Baek-Yeol RyooEmail author


Lanreotide autogel is a long-acting somatostatin analogue with proven efficacy and safety in patients with well-differentiated (WD) gastroenteropancreatic-neuroendocrine tumors (GEP-NETs) in a prior randomized phase III trial (CLARINET). However, the CLARINET study only enrolled patients with Ki-67 index <10%, and few patients of Asian ethnicity were included. We retrospectively analyzed the efficacy and safety of lanreotide in Korean patients with GEP-NETs in the daily practice setting. Between January 2015 and May 2018, 64 patients with metastatic WD GEP-NETs received lanreotide at Asan Medical Center, Seoul, Korea. Of them, 45 (70.3%) patients who received lanreotide as monotherapy were included in the current analysis. The most common primary tumor site was the pancreas (n = 22, 48.9%), followed by the rectum (10, 22.2%) and the small bowel (7, 15.6%). According to RECIST v1.1, a partial response was achieved in one patient (2.2%) and stable disease was achieved in 40 patients (88.9%). The median progression-free survival (PFS) was 16.4 months (95% confidence interval, 9.5–23.3 months). There were no differences in PFS according to the primary tumor site (p = 0.77). Hepatic tumor volume > 25% and prior systemic therapy were significantly associated with poorer PFS in the multivariate analysis. Lanreotide is well-tolerated and effective for Korean patients with GEP-NETs in the daily practice setting.


Neuroendocrine tumor Somatostatin analogue Lanreotide 


Compliance with ethical standards

Conflicts of interest

The authors have no competing financial interests to declare.

Statement of ethics

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

For this type of study, formal consent is not required.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Junho Kang
    • 1
  • Changhoon Yoo
    • 1
    Email author
  • Hee-Sang Hwang
    • 2
  • Seung-Mo Hong
    • 2
  • Kyu-pyo Kim
    • 1
  • Sun Young Kim
    • 1
  • Yong-Sang Hong
    • 1
  • Tae Won Kim
    • 1
  • Baek-Yeol Ryoo
    • 1
    Email author
  1. 1.Department of Oncology, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulSouth Korea
  2. 2.Department of Pathology, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulSouth Korea

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