HCCs and HCAs in Non-cirrhotic Patients: What You See May Not Be Enough
Case 1 A previously healthy 16-year-old man was initially evaluated in the emergency department for traumatic injuries following a high-impact motor vehicle accident. He was a bodybuilder who used anabolic steroids. He denied abdominal or back pain. His physical examination was significant for a palpable liver edge. Routine laboratory tests including liver function tests were unremarkable. A computed tomographic (CT) scan showed an unsuspected mass in the right lobe of the liver. A subsequent triple-phase magnetic resonance imaging (MRI) scan of the abdomen showed a 15.1 × 15.0 × 10.8 cm mass in the right hepatic lobe that exhibited heterogeneous arterial and thin capsular enhancement, concerning for a hepatic neoplasm (Fig. 1). He underwent partial hepatectomy; the resected surgical specimen showed a well-differentiated hepatocellular carcinoma that on immunohistochemical staining (Fig. 2a) showed β-catenin activation via aberrant nuclear expression. The tumor was...
KeywordsHepatocellular carcinoma Hepatic adenoma Non-cirrhotic β-catenin Anabolic steroids Contraceptives Glycogen storage disease Liver transplantation
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 22.Solbach P, Potthoff A, Raatschen HJ, et al. Testosterone-receptor positive hepatocellular carcinoma in a 29-year old bodybuilder with a history of anabolic androgenic steroid abuse: a case report. BMC Gastroenterol. 2015;15:60. https://doi.org/10.1186/s12876-015-0288-0.CrossRefPubMedPubMedCentralGoogle Scholar
© Springer Science+Business Media, LLC, part of Springer Nature 2019