Digestive Diseases and Sciences

, Volume 64, Issue 12, pp 3557–3567 | Cite as

Endoscopic Balloon Dilation for Benign Bilioenteric Stricture: Outcomes and Factors Affecting Recurrence

  • Hiroshi YamauchiEmail author
  • Mitsuhiro Kida
  • Eiji Miyata
  • Kosuke Okuwaki
  • Tomohisa Iwai
  • Naoki Minato
  • Masayoshi Tadehara
  • Masafumi Watanabe
  • Hiroshi Imaizumi
  • Wasaburo Koizumi
Original Article



Balloon dilation (BD) is a simple, effective procedure for postoperative benign bilioenteric strictures (BBESs). Factors associated with BBES recurrence after endoscopic BD have not been studied adequately. This study examined the outcomes and 1-year recurrence factors in patients with BBES who underwent endoscopic BD.


Patients who underwent endoscopic BD as an initial treatment between April 2008 and March 2017 were retrospectively assessed. The median time to recurrence of BBES (RBBES) and recurrence factors were evaluated.


The study group comprised 55 patients (median age 72 years). The rate of RBBES was 52.7% (29/55), and the median time to RBBES was 2.78 years (95% confidence interval [CI] 1.17–4.40). RBBES was observed in 32.7% (18/55) within 1 year after endoscopic BD. The significant factors associated with recurrence within 1 year, revealed by multivariate analysis, were: postoperative bile leak (p = 0.001; hazard ratio [HR] 10.94; 95% CI 2.47–48.39); BBES onset within 6 months, postoperatively (p = 0.013; HR 6.18; 95% CI 1.46–26.21); no intrahepatic stones (p = 0.049; HR 3.05; 95% CI 1.01–9.22); and remaining balloon waist (p = 0.005; HR 5.71; 95% CI 1.69–19.31). The median time to RBBES was significantly shorter in patients with these recurrence factors (0.88 years vs. not reached, p = 0.004). Patients exhibiting at least two recurrence factors were significantly more likely to experience recurrence (p < 0.001).


Endoscopic BD is effective for BBES, especially for patients with no recurrence factors. Consideration of endoscopic BD and additional treatment may be necessary for patients with recurrence factors.


Bilioenteric stricture Endoscopic balloon dilation Balloon enteroscopy Surgically altered anatomy 



The authors thank Olympus Medical Systems (Tokyo, Japan) for providing the prototype instruments used in this study.



Compliance with Ethical Standards

Conflict of interests



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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Hiroshi Yamauchi
    • 1
    Email author
  • Mitsuhiro Kida
    • 1
  • Eiji Miyata
    • 1
  • Kosuke Okuwaki
    • 1
  • Tomohisa Iwai
    • 1
  • Naoki Minato
    • 1
  • Masayoshi Tadehara
    • 1
  • Masafumi Watanabe
    • 1
  • Hiroshi Imaizumi
    • 1
  • Wasaburo Koizumi
    • 1
  1. 1.Department of GastroenterologyKitasato University School of MedicineSagamihara CityJapan

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