Low Sensitivity of Fecal Immunochemical Tests (FIT) for Detection of Sessile Serrated Adenomas/Polyps Confirmed Over Clinical Setting, Geography, and FIT System
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We were interested to read the study of Cock et al.  on the clinical sensitivity of fecal immunochemical tests (FIT) for the detection of sessile serrated adenomas/polyps (SSA/SSP), and their conclusion that FIT have low sensitivity for their detection.
Participants in their study were aged over 18 years and underwent colonoscopy in South Australia with FIT analyses performed on the OC-Sensor Diana (Eiken Chemical Co., Ltd, Tokyo, Japan). Indications for colonoscopy were heterogeneous and were as follows: positive FIT 519 (27.6%), symptoms 561 (29.8%), surveillance 687 (36.5%), screening 18 (1.0%), and other 97 (5.2%). However, it is known that the performance outcomes using FIT vary in different clinical settings and different fecal hemoglobin concentrations (f-Hb) are used as thresholds [2, 3]. In addition, quantitative FIT systems use polyclonal antibodies to the globin moiety of human hemoglobin and have different analytical specificities, giving different f-Hb...
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Conflict of interest
CGF undertakes paid consultancy with Kyowa Medex Co., Ltd, Tokyo, Japan, and has received financial assistance with attendance at conferences from Alpha Labs Ltd. All other authors declare that they have no conflicts of interest.
- 1.Cock C, Anwar S, Byrne SE, et al. Low sensitivity of fecal immunochemical tests and blood-based markers of DNA hypermethylation for detection of sessile serrated adenomas/polyps. Dig Dis Sci. 2019. (Epub ahead of print). https://doi.org/10.1007/s10620-019-05569-8.
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