Effect of Preceding Biopsy on the Results of Endoscopic Submucosal Dissection for Colorectal Laterally Spreading Tumor
- 100 Downloads
Forceps biopsies are usually performed before endoscopic submucosal dissection (ESD) for colonic laterally spreading tumors (LSTs). However, preceding biopsy is commonly believed to possibly inhibit complete tumor resection by causing blurring of tumor borders and tissue fibrosis.
The aims were to investigate whether the preceding biopsy of colorectal LST affects the complete endoscopic tumor resection and increases the risk of complications.
We retrospectively reviewed the medical records of patients with colorectal LSTs who underwent ESD at our center during an 8-year period. Patients were divided into two groups according to whether they underwent biopsy of the tumor before ESD. In addition, the characteristics of patients and tumors, including the completeness of tumor resection, were investigated.
Of 288 patients (174 men) enrolled in this study, 194 (67.4%, preceding biopsy group) underwent biopsies before ESD, whereas 94 (32.6%, no biopsy group) did not. There were no significant differences in age, sex, comorbidity, medication history, tumor location, and final pathologic result between both groups. Tumor size was larger (p = 0.002) and LST-G tumor was more common (p = 0.003) in the preceding biopsy group than in the no biopsy group. No significant difference was seen in ESD outcomes, including procedure time, hospitalization period, incidence of complications, en bloc resection rate, resection margin status, and incidence of surgical operation, between both groups.
Biopsy of LST is commonly performed before endoscopic resection. Contrary to popular belief, it does not increase the incomplete tumor resection rate and incidence of complications.
KeywordsLaterally spreading tumor Endoscopic submucosal dissection Biopsy Colorectal neoplasms
Laterally spreading tumor
Endoscopic submucosal dissection
Endoscopic mucosal resection
SPL contributed to study concept, design, analysis of data, and drafting of the manuscript. IKS contributed to study concept, interpretation of data, and drafting of the manuscript. JHK, SYL, HSP, and CSS acquired the data and critically revised the manuscript.
This work was supported by Konkuk University Medical Center Research Grant 2016.
Compliance with ethical standards
Conflict of interest
All authors disclose no financial relationships relevant to this publication.
The study protocol was approved by the Institutional Review Board of Konkuk University Medical Center (KUH1010861).
- 18.Lee SP, Sung IK, Kim JH, et al. A randomized controlled trial of prophylactic antibiotics in the prevention of electrocoagulation syndrome after colorectal endoscopic submucosal dissection. Gastrointest Endosc. 2017;86:349.e342–357.e342.Google Scholar