Capsule-Delivered Fecal Microbiota Transplant Is Safe and Well Tolerated in Patients with Ulcerative Colitis
Fecal microbiota transplantation (FMT) has emerged as a potential therapy for ulcerative colitis (UC). Several randomized, placebo-controlled trials have shown promise for FMT to induce remission in active UC with lower gastrointestinal administration (colonoscopy/enema) followed by frequent enema maintenance . Clinical remission rates appear higher with maintenance dosing in contrast to a single administration [2, 3]; however, FMT enemas may be burdensome for long-term therapy, and FMT delivered by capsules (cap-FMT) is preferred by patients . Although single-dose administration of cap-FMT is safe for the prevention of recurrent C. difficile infection (rCDI) in those with underlying inflammatory bowel disease (IBD) [5, 6], it is unknown whether frequent maintenance dosing of cap-FMT is safe and well tolerated in UC patients. Accordingly, we aimed to investigate the safety and tolerability of cap-FMT in UC patients as a maintenance regimen following FMT via...
Our study was funded by an Anonymous Philanthropic Gift.
Compliance with ethical standards
Conflict of interest
ZK is an employee/shareholder of Finch Therapeutics. No other relevant disclosures or financial conflicts of interest.
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