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Digestive Diseases and Sciences

, Volume 64, Issue 10, pp 3001–3012 | Cite as

Determinants of Hepatitis C Treatment Adherence and Treatment Completion Among Veterans in the Direct Acting Antiviral Era

  • Krupa PatelEmail author
  • Susan L. Zickmund
  • Harleigh Jones
  • Andrea Reid
  • Linda Calgaro
  • Arielle Otero
  • Tami Coppler
  • Shari S. Rogal
Original Article

Abstract

Background

Despite the availability of direct acting antiviral medications (DAAs), there are ongoing concerns about adherence to hepatitis C virus (HCV) treatment. We sought to understand the barriers to and facilitators of DAA adherence in the Veteran population.

Methods

Patients completed semi-structured interviews focused on barriers to and facilitators of HCV treatment adherence both pre- and post-DAA treatment. Adherence was assessed via provider pill count and self-report. Thematic analyses were conducted in the qualitative software program Atlas.ti in order to understand anticipated barriers to and facilitators of treatment adherence and completion. Charts were reviewed for clinical data and sustained virologic response (SVR12).

Results

Of 40 patients, 15 had cirrhosis and 10 had prior interferon-based treatment. Pre-treatment interviews revealed anticipated barriers to adherence such as side effects (n = 21) and forgetting pills (n = 11). Most patients (n = 27) reported following provider advice, and others had unique reasons not to (e.g., feeling like a “guinea pig”). Post-treatment interviews uncovered facilitators of treatment including wanting to cure HCV (n = 17), positive results (n = 18), and minimal side effects (n = 15). Three patients (8%) did not complete therapy (whom we further elaborate on) and 6 (15%) missed doses but completed treatment. SVR12 was achieved by all participants who completed therapy (93%). Patients who did not complete therapy or missed doses were all treatment naïve, mostly non-cirrhotic (8 of 9), and often anticipated concerns with forgetting their medications.

Conclusions

This qualitative study uncovered several unanticipated determinants of HCV treatment completion and provides rationale for several targeted interventions such as incorporating structured positive reinforcement.

Keywords

Interferon-free Compliance Patient-centered Reminders Relapse 

Notes

Funding

The funding was provided by Gilead Sciences.

Compliance with ethical standards

Conflict of interest

The authors have no conflicts of interest to report related to this study.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of General Internal MedicineUniversity of Pittsburgh School of MedicinePittsburghUSA
  2. 2.Informatics, Decision-Enhancement and Analytic Sciences Center (IDEAS 2.0), VA Salt Lake City Health Care SystemSalt Lake CityUSA
  3. 3.Division of Epidemiology, Department of Internal MedicineUniversity of Utah School of MedicineSalt Lake CityUSA
  4. 4.VA Pittsburgh Healthcare SystemPittsburghUSA
  5. 5.Gastroenterology, Hepatology, and Nutrition SectionWashington DC VA Medical CenterWashingtonUSA
  6. 6.Division of Gastroenterology, Hepatology, and NutritionUniversity of PittsburghPittsburghUSA
  7. 7.Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare SystemPittsburghUSA
  8. 8.Department of SurgeryUniversity of PittsburghPittsburghUSA

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