Case Report of a Proposed, Novel, Endoscopic “Whitehead Pimple” Sign of Ectopic Esophageal Sebaceous Glands Based on Their Mimicking the Dermatologic and Histopathologic Characteristics of Cutaneous Whitehead Pimples/Closed Comedones
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Endoscopic signs help characterize endoscopic lesions. The endoscopic appearance of esophageal ectopic sebaceous glands (ESGs/Fordyce lesions) has been described in several case reports [1, 2], but none have described its endoscopic appearance as potentially characteristic or mimicking a type of cutaneous sebaceous glands. This report describes that its endoscopic appearance and histopathology mimics that of cutaneous closed comedones (colloquially, whitehead pimples), explains the pathophysiology, and reports a novel potentially diagnostic endoscopic sign.
KeywordsEctopic sebaceous glands Fordyce spots Comedones Esophagus Esophagogastroduodenoscopy Endoscopic sign
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Conflict of interest
None. In particular, Dr. Cappell, as a consultant of the United States Food and Drug Administration (FDA) Advisory Committee for Gastrointestinal Drugs, affirms that this paper does not discuss any proprietary confidential pharmaceutical data submitted to the FDA. Dr. Cappell was a member of the speaker’s bureau for AstraZeneca and Daiichi Sankyo, co-marketers of Movantik and did receive one-time consulting fees from Mallinckrodt and Shire. This work does not discuss any drug manufactured or marketed by AstraZeneca, Daiichi Sankyo, Shire, or Mallinckrodt.
This study received approval from the IRB of William Beaumont Hospital at Royal Oak on June 27, 2018.