Digestive Diseases and Sciences

, Volume 64, Issue 1, pp 281–282 | Cite as

Risk of Rebleeding After Hemostasis for Peptic Ulcer

  • Antonio Ponzetto
  • John Holton

Dear Sir,

The important observation by Kondo et al. [1] reports the high risk of rebleeding after hemostasis of peptic ulcer. They analyze the risk factors and find that a high dose of steroids is an important one [1]. We concur; however, we believe a further risk factor should also be analyzed, i.e., the presence or not of Helicobacter pylori infection; indeed, Asaka et al. [2] reported a 66% rate of rebleeding due to peptic ulcer (PU) in Japanese patients who failed to eradicate this bacterium. We and others in Italy found that rebleeding was very rare after successful cure of H. pylori [3, 4]. One important observation is that during the acute phase of PU bleeding very often gastric biopsies lead to a false negative for the presence of H. pylori, as clearly stated by the Maastricht V/Florence consensus report [5]. This observation highlights the need for multiple tests for the detection of this bacterium in all patients, but more so in the bleeding ones [5]. Recently, Takatori et...


Author’s contribution

AP conceived the writing, and all authors contributed to the completion and approval of the letter.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Medical SciencesUniversity of TurinTurinItaly
  2. 2.National Mycobacterial Reference Unit National Mycobacterium Reference Laboratory (NMRL) Abernethy BuildingInstitute of Cell and Molecular Science (ICMS)LondonUK

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