Successful DAA Treatment and Global Improvement in a Cirrhotic Patient with Concomitant HCV Infection and Autoimmune Hepatitis
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Hepatitis C virus (HCV) infection has been linked to the development of autoimmunity, in part through activation of B cells, which also plays a pathogenic role in autoimmune diseases of the liver . Since excessive immune response against HCV may promote autoimmunity, it is reasonable to consider this added benefit of HCV eradication by direct-acting antiviral (DAA), although there may be concerns related to recent reports of DAA-induced AIH in patients treated for HCV . Here, we describe the case of a patient with chronic HCV infection and AIH who was successfully treated with DAA, and who showed a considerable improvement in global liver function after viral clearance.
KeywordsAutoimmune hepatitis Azathioprine Hepatitis C virus Cirrhosis Direct-acting antivirals Outcome
Compliance with ethical standards
Conflict of interest
No financial support was received for this study. The author has no personal interests to declare.
Informed consent was obtained from the patient. No IRB approval is required at our institution for case reports.