Digestive Diseases and Sciences

, Volume 64, Issue 2, pp 532–543 | Cite as

Epidemiological Trends in Gastrointestinal Cancers in China: An Ecological Study

  • Liting Xi
  • Jinzhou Zhu
  • Huixian Zhang
  • Merlin Muktiali
  • Chunfang Xu
  • Airong WuEmail author
Original Article



In recent decades, the patterns and trends of gastrointestinal (GI) cancer epidemics in Chinese population have been changing.


To present the epidemiological trends and geographic distributions of four major GI cancers (esophageal cancer, stomach cancer, liver cancer and colorectal cancer) in China from 2010 to 2014.


It used standardized data extracted from the National Central Cancer Registry database.


The age-standardized incidence rates (ASIR) of esophageal cancer decreased from 16.7 to 12.2 per 100,000 and the age-standardized mortality rates (ASMR) decreased from 12.0 to 8.8 per 100,000. The ASIR and the ASMR of stomach cancer dropped from 23.7 to 19.5 per 100,000 and from 16.6 to 13.3 per 100,000. The ASIR of liver cancer fell from 21.4 to 17.8 per 100,000 and its ASMR fell from 18.4 per 100,000 to 15.3 per 100,000. The ASIR of colorectal cancer increased from 16.1 to 17.5 per 100,000, whereas the ASMR fluctuated between 7.6 and 7.9 per 100,000. Moreover, the incidence and mortality of each cancer differed between males and females, urban and rural residence, as well as various regions.


From 2010 to 2014, esophageal cancer, stomach cancer and liver cancer showed downward trend, while the ASIR of colorectal cancer slightly rose and its ASMR presented stable.


Esophageal cancer Stomach cancer Liver cancer Colorectal cancer National Central Cancer Registry (NCCR) Epidemiology 



The work was supported by Jiangsu Provincial Key Research and Development Plan (No. BE2018659).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

10620_2018_5335_MOESM1_ESM.tif (252 kb)
Fig. S1 Percentages of current tobacco smoking in China, by gender (2000–2015). Data source: WHO. WHO global report on trends in tobacco smoking 2000–2015. (TIFF 252 kb)
10620_2018_5335_MOESM2_ESM.tif (175 kb)
Fig. S2 Trends in the prevalence (%) of overweight and obesity among adults (aged ≧ 18 years old) in China (1992–2012). Data source: China National Nutrition and Health Survey (CNNHS) (1992–2012), the largest nationally representative survey in China conducted every 10 years. According to the Chinese standard, obesity was defined as BMI ≧ 28 kg/m2 and overweight was defined as 28 > BMI ≧ 24 kg/m2. (TIFF 174 kb)
10620_2018_5335_MOESM3_ESM.tif (196 kb)
Fig. S3 Changes in the food intake in Chinese daily diet (2002–2012). Data source: China National Nutrition and Health Survey (CNNHS) (1992–2012), the largest nationally representative survey in China conducted every 10 years. (TIFF 196 kb)
10620_2018_5335_MOESM4_ESM.docx (11 kb)
Supplementary material 4 (DOCX 11 kb)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Liting Xi
    • 1
  • Jinzhou Zhu
    • 1
  • Huixian Zhang
    • 1
  • Merlin Muktiali
    • 2
  • Chunfang Xu
    • 1
  • Airong Wu
    • 1
    Email author
  1. 1.Department of GastroenterologyThe First Affiliated Hospital of Soochow UniversitySuzhouChina
  2. 2.Department of OncologyThe First Affiliated Hospital of Soochow UniversitySuzhouChina

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