Digestive Diseases and Sciences

, Volume 64, Issue 2, pp 345–348 | Cite as

Blood and Guts: Diarrhea from Colonic Involvement in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

  • Thomas A. Zikos
  • George TriadafilopoulosEmail author
  • Caroline Berube
  • Kirsten A. Regalia
Stanford Multidisciplinary Seminars

Case Presentation and Evolution

An 81-year-old male was initially evaluated in a local emergency department for a 6-week history of diarrhea. He had a history of coronary artery disease with remote coronary artery bypass graft and mechanical mitral valve placement, for which he was maintained on warfarin. He also had chronic obstructive pulmonary disease with chronic hypoxemic respiratory insufficiency for which he received continuous oxygen at a rate of 2 L/min. Prior to the onset of diarrhea, he had no chronic gastrointestinal (GI) symptoms. The diarrhea began acutely, was non-bloody, and eventually progressed to more than ten bowel movements daily. While he denied abdominal pain, fevers, chills, or nausea, he sustained a 10-pound weight loss during this time. There was no family history of inflammatory bowel disease.

On presentation, his laboratory results included a white blood cell count of 28.0 × 10 3/μL (of which 44% were atypical lymphocytes), hemoglobin 12.1 g/dL, platelet...


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Thomas A. Zikos
    • 1
  • George Triadafilopoulos
    • 1
    Email author
  • Caroline Berube
    • 2
  • Kirsten A. Regalia
    • 1
  1. 1.Division of Gastroenterology and HepatologyStanford University School of MedicineStanfordUSA
  2. 2.Division of Hematology and OncologyStanford University School of MedicineStanfordUSA

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