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Digestive Diseases and Sciences

, Volume 63, Issue 10, pp 2500–2506 | Cite as

Gut Movements: A Review of the Physiology of Gastrointestinal Transit

  • Dennis Kumral
  • Alvin M. Zfass
Mentored Reviews
  • 423 Downloads

Abstract

The well-regulated mechanisms of intestinal transit favor aboral movement of intestinal contents during the formation of normal stool. Electrical pacemakers initiate mechanical smooth muscular propulsion under regulation by the enteric nervous system—a function of the “brain-gut axis.” Several unique intestinal motor patterns function in concert to enhance the activities of intestinal transit. Development of pharmacologic targets of intestinal transit mechanisms afford clinicians control in the management of functional gastrointestinal disorders. This review highlights the important physiologic events of intestinal transit, discusses selected pharmacologic and neuromodulators involved in these processes, and provides relevant clinical correlates to physiologic events.

Keywords

Intestinal transit Gastrointestinal physiology Gastrointestinal transit Peristalsis Gastrointestinal pharmacology 

Notes

Compliance with ethical standards

Conflict of interest

The authors have no relevant financial disclosures to report.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of GastroenterologyVirginia Commonwealth UniversityRichmondUSA
  2. 2.Division of Gastroenterology, 111NHunter Holmes McGuire Veterans Affairs Medical CenterRichmondUSA

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