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Digestive Diseases and Sciences

, Volume 63, Issue 11, pp 3126–3133 | Cite as

Influence of Obesity and Metabolic Abnormalities on the Risk of Developing Colorectal Neoplasia

  • Nam Hee Kim
  • Yoon Suk Jung
  • Jung Ho Park
  • Dong Il Park
  • Chong Il Sohn
Original Article

Abstract

Background

Obesity and metabolic syndrome are risk factors for colorectal neoplasia (CRN). However, the association between metabolically healthy obese (MHO) or metabolically unhealthy non-obese (MUNO) status and the risk of CRN remains unclear.

Aims

We aimed to elucidate the association between MHO or MUNO status and the risk of CRN.

Methods

A total of 139,023 asymptomatic subjects who underwent a primary screening colonoscopy were categorized into 4 groups according to obesity and metabolic status: metabolically healthy non-obese (MHNO), MHO, MUNO, and metabolically unhealthy obese (MUO).

Results

Mean participant age was 41.0 years, and the proportion of men was 65.3%. Among men, the risk of overall CRN increased in MHO (adjusted odds ratio [AOR] 1.22, 95% confidence intervals [CI] 1.12–1.33), MUNO (AOR 1.25, 95% CI 1.18–1.31), and MUO groups (AOR 1.47, 95% CI 1.40–1.54) compared with the MHNO group, whereas the risk of advanced CRN (ACRN) increased in MUNO (AOR 1.16, 95% CI 1.002–1.33) and MUO groups (AOR 1.49, 95% CI 1.31–1.70), but not in the MHO group (AOR 0.92, 95% CI 0.70–1.21). Moreover, among non-obese men, the risk of overall CRN and ACRN linearly increased with an increasing number of metabolic abnormalities. However, among women, only the MUO group had an increased risk of overall CRN (AOR 1.34, 95% CI 1.21–1.47) and no other significant associations were observed.

Conclusions

Poor metabolic health, regardless of obesity, is an independent risk factor for CRN in men. Our results suggest that men with metabolic abnormalities should be considered as a high-risk group for colorectal cancer, even if they are not obese.

Keywords

Metabolic abnormalities Obesity Colorectal neoplasia 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Preventive Healthcare Center, Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulKorea
  2. 2.Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulKorea

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