Digestive Diseases and Sciences

, Volume 63, Issue 11, pp 3134–3140 | Cite as

Heavy Coffee Consumption and Risk of Pancreatitis: A Systematic Review and Meta-Analysis

  • Karn WijarnpreechaEmail author
  • Panadeekarn Panjawatanan
  • Omar Y. Mousa
  • Wisit Cheungpasitporn
  • Surakit Pungpapong
  • Patompong Ungprasert
Original Article



Heavy consumption of coffee may have a protective effect against pancreatitis although results from previous studies were inconsistent. This meta-analysis was conducted with the aim to summarize all available data.


This meta-analysis included observational studies that compared the risk of pancreatitis between heavy coffee-drinkers and individuals who were not heavy coffee-drinkers. Pooled risk ratios (RRs) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method.


Out of 219 retrieved articles, four studies with 351,137 participants met the eligibility criteria and were included in the analysis. The risk of pancreatitis among heavy coffee-drinkers was significantly lower than individuals who were not heavy coffee-drinkers with the pooled RR of 0.78 (95% CI 0.67–0.91). The statistical heterogeneity between the studies was insignificant (I2 = 0%).


This meta-analysis demonstrated a significantly decreased risk of pancreatitis among heavy coffee-drinkers. However, further investigations are still required to determine causality and potential clinical application.


Pancreatitis Coffee Caffeine Meta-analysis 


Author’s contribution

All authors had access to the data and a role in writing the manuscript.



Compliance with ethical standards

Conflict of interest

The authors have no commercial associations that might be a conflict of interest in relation to this article.

Supplementary material

10620_2018_5214_MOESM1_ESM.doc (28 kb)
Supplementary material 1 (DOC 28 kb)
10620_2018_5214_MOESM2_ESM.doc (64 kb)
Supplementary material 2 (DOC 64 kb)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Internal MedicineBassett Medical CenterCooperstownUSA
  2. 2.Department of Biochemistry, Faculty of MedicineChiang Mai UniversityChiang MaiThailand
  3. 3.Division of Gastroenterology and Hepatology, Mayo Clinic College of MedicineMayo ClinicJacksonvilleUSA
  4. 4.Department of Medicine, Division of NephrologyUniversity of Mississippi Medical CenterJacksonUSA
  5. 5.Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand

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