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Digestive Diseases and Sciences

, Volume 63, Issue 11, pp 2992–2997 | Cite as

Sleep Disturbances Can Be Prospectively Observed in Patients with an Inactive Inflammatory Bowel Disease

  • Ariella Bar-Gil Shitrit
  • Chen Chen-Shuali
  • Tomer Adar
  • Benjamin Koslowsky
  • Shimon Shteingart
  • Kalman Paz
  • Sorina Grisaru-Granovsky
  • Eran Goldin
  • Gali Epstein Shochet
  • David Shitrit
Original Article

Abstract

Background

Poor sleep quality is associated with adverse health consequences. Sleep disturbances can impact the immune function and inflammatory processes. Little is known about sleep disturbances in patients with inflammatory bowel disease (IBD), while not in flare, i.e., inactive.

Aims

To prospectively explore the sleep quality of patients with an inactive IBD.

Methods

This pilot study included 36 consecutive patients with IBD and 27 healthy volunteers. All IBD patients had an inactive disease. Participants underwent an overnight ambulatory polysomnography. Data on disease duration, medications, complications, and treatment were collected from the medical records.

Results

The mean age of the IBD and the control groups was 39 ± 15 and 34.6 ± 9.6 years. A significantly less rapid eye movement (REM) sleep was noted in the IBD group vs. control (23.7 vs. 27.8%, p = 0.047); light sleep percentage and REM latency were also longer in the IBD group. Moreover, oxygen desaturation below 90% was more common in the IBD group. All other sleep parameters including respiratory disturbance index, apnea–hypopnea index, number of wakes, sleep latency, and snoring strength were similar in both groups.

Conclusions

Inactive IBD is associated with sleep disturbances. A larger prospective study should be conducted to confirm these findings.

Keywords

Inflammatory bowel disease Sleep Oximetry Polysomnography Crohn’s disease 

Notes

Author’s contribution

ABS, CCS, and DS had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis, including and especially any adverse effects. TA, BK, KP, SS, SGG, EG, GES, CCS, ABS, and DS contributed substantially to the study design, data analysis and interpretation, and the writing of the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee (Human Subjects Protection Program of SZMC) and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Ariella Bar-Gil Shitrit
    • 1
    • 4
  • Chen Chen-Shuali
    • 2
    • 4
  • Tomer Adar
    • 1
    • 4
  • Benjamin Koslowsky
    • 1
    • 4
  • Shimon Shteingart
    • 1
    • 4
  • Kalman Paz
    • 1
    • 4
  • Sorina Grisaru-Granovsky
    • 3
    • 4
  • Eran Goldin
    • 1
    • 4
  • Gali Epstein Shochet
    • 5
    • 6
  • David Shitrit
    • 5
    • 6
  1. 1.Department of GastroenterologyShaare Zedek Medical CenterJerusalemIsrael
  2. 2.Pulmonary DepartmentShaare Zedek Medical CenterJerusalemIsrael
  3. 3.Obstetric DepartmentShaare Zedek Medical CenterJerusalemIsrael
  4. 4.Hebrew University of Jerusalem, School of MedicineJerusalemIsrael
  5. 5.Pulmonary DepartmentMeir Medical CenterKfar SabaIsrael
  6. 6.Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael

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