Sleep Disturbances Can Be Prospectively Observed in Patients with an Inactive Inflammatory Bowel Disease
Poor sleep quality is associated with adverse health consequences. Sleep disturbances can impact the immune function and inflammatory processes. Little is known about sleep disturbances in patients with inflammatory bowel disease (IBD), while not in flare, i.e., inactive.
To prospectively explore the sleep quality of patients with an inactive IBD.
This pilot study included 36 consecutive patients with IBD and 27 healthy volunteers. All IBD patients had an inactive disease. Participants underwent an overnight ambulatory polysomnography. Data on disease duration, medications, complications, and treatment were collected from the medical records.
The mean age of the IBD and the control groups was 39 ± 15 and 34.6 ± 9.6 years. A significantly less rapid eye movement (REM) sleep was noted in the IBD group vs. control (23.7 vs. 27.8%, p = 0.047); light sleep percentage and REM latency were also longer in the IBD group. Moreover, oxygen desaturation below 90% was more common in the IBD group. All other sleep parameters including respiratory disturbance index, apnea–hypopnea index, number of wakes, sleep latency, and snoring strength were similar in both groups.
Inactive IBD is associated with sleep disturbances. A larger prospective study should be conducted to confirm these findings.
KeywordsInflammatory bowel disease Sleep Oximetry Polysomnography Crohn’s disease
ABS, CCS, and DS had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis, including and especially any adverse effects. TA, BK, KP, SS, SGG, EG, GES, CCS, ABS, and DS contributed substantially to the study design, data analysis and interpretation, and the writing of the manuscript.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee (Human Subjects Protection Program of SZMC) and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
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