Digestive Diseases and Sciences

, Volume 63, Issue 10, pp 2792–2799 | Cite as

Effect of Metabolic Syndrome on the Clinical Outcomes of Chronic Hepatitis B Patients with Nucleos(t)ide Analogues Treatment

  • Nam Hee Kim
  • Yong Kyun Cho
  • Byung Ik Kim
  • Hong Joo Kim
Original Article



No data are available about the effect of MS on oral nucleos(t)ide analogues (NUCs) treatment and clinical outcomes in chronic hepatitis B (CHB) patients.


We aimed to elucidate whether coexistence of MS and CHB affects the long-term prognosis of CHB patients with oral NUCs treatment.


We performed a retrospective data analysis for a total of 587 CHB patients who started oral NUCs treatment for the first time in our institution from January 2006 to March 2016.


Among the 587 patients, 70 (11.9%) had MS, but 517 (88.1%) had no evidence of MS when oral NUCs treatment was initiated. Cumulative occurrence rates of viral breakthrough, genotypic resistance, HCC, disease progression (PD), and overall adverse outcomes (OAO) were significantly higher in CHB patients with MS than in those without MS, although HBV-DNA suppression and cumulative occurrence rates of HBeAg negative conversion and seroconversion were not significantly different between the two groups. The overall survival (OS) was also significantly shorter in CHB patients with MS than in those without MS. Multivariate analysis indicated that the MS was an independent, poor prognostic factor for occurrence of genotypic resistance (adjusted hazard ratio [aHR], 22.3; 95% confidence interval [CI] 6.61–75.02; P < 0.001), HCC (aHR, 3.98; 95% CI 2.07–7.66; P < 0.001), PD (aHR, 6.18; 95% CI 3.43–11.14; P < 0.001), OAO (aHR, 8.10; 95% CI 4.68–14.02; P < 0.001), and OS (aHR, 12.29; 95% CI 2.25–67.24; P < 0.001).


MS is an independent determinant of poor prognosis in CHB patients receiving oral NUCs treatment.


Metabolic syndrome Nucleos(t)ide analogue Hepatocellular carcinoma Disease progression Survival 


Compliance with ethical standards

Conflict of interest

All authors declare that they have no competing conflicts of interests.

Supplementary material

10620_2018_5165_MOESM1_ESM.tif (1.7 mb)
Supplementary Fig. 1 (A) CR rate (P < 0.198) and (B) ALT normalization rate (p < 0.001) in CHB patients with vs. without metabolic syndrome (TIFF 1726 kb)
10620_2018_5165_MOESM2_ESM.tif (1003 kb)
Supplementary Fig. 2 (A) Cumulative occurrence rates of HBeAg negative conversion (P = 0.434) and (B) seroconversion (P = 0.119) in CHB patients with vs. without metabolic syndrome (TIFF 1003 kb)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Preventive Healthcare Center, Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulKorea
  2. 2.Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulKorea

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