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Digestive Diseases and Sciences

, Volume 63, Issue 10, pp 2810–2812 | Cite as

Extensive Gastrointestinal Manifestations as the Main Relapsing Disease in Granulomatosis with Polyangiitis

  • Omar Vergara-Fernández
  • Fredy Chablé-Montero
  • Natllely Ruiz
  • David Mitre-Reyes
  • Eduardo Cerda-Contreras
  • Andrea Hernández
  • Erika Marroquín-Fabián
  • Luis Felipe Flores-Suárez
Case Report
  • 46 Downloads

Granulomatosis with polyangiitis (GPA-Wegener’s) is a small vessel vasculitis associated with the presence of antineutrophil cytoplasm autoantibodies. Gastrointestinal involvement ranges from 5 to 20% of cases. We describe a case in whom relapsing disease with widespread gastrointestinal manifestations including pharyngeal, esophageal, small and large intestine, and anus was present for the first time.

A 43-years-old male, with a 10-year history of proteinase-3 (PR3-ANCA) positive GPA which presented initially with general (fever, malaise), articular, otorhinolaryngological, ocular (scleritis), and pulmonary manifestations (nodular disease, biopsy-proven), was treated with glucocorticoids (GC) and methotrexate (MTX) as remission induction therapy, followed by MTX as maintenance treatment for 5 years. After remission was achieved at month 6, gradual tapering of MTX during the following 4.5 years allowed for its withdrawal in 2010. He already had a history of a hemorrhoidal disease,...

Keywords

Granulomatosis with polyangiitis ANCA Vasculitis Gastrointestinal Anorectal 

Notes

Acknowledgements

We thank Debora Bork, MA, for reviewing the article’s grammatical structure, and Mr. Jorge Velázquez for image editing.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Omar Vergara-Fernández
    • 1
  • Fredy Chablé-Montero
    • 2
  • Natllely Ruiz
    • 3
  • David Mitre-Reyes
    • 1
  • Eduardo Cerda-Contreras
    • 4
  • Andrea Hernández
    • 5
  • Erika Marroquín-Fabián
    • 3
  • Luis Felipe Flores-Suárez
    • 3
    • 6
  1. 1.Colorectal SurgeryMédica Sur HospitalMexico CityMexico
  2. 2.Department of Pathologic AnatomyMédica Sur HospitalMexico CityMexico
  3. 3.Primary Systemic Vasculitides ClinicInstituto Nacional de Enfermedades RespiratoriasMexico CityMexico
  4. 4.Gastroenterology and Endoscopy ServicesMédica Sur HospitalMexico CityMexico
  5. 5.Internal Medicine ResidentMédica Sur HospitalMexico CityMexico
  6. 6.RheumatologyMédica Sur HospitalMexico CityMexico

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