Digestive Diseases and Sciences

, Volume 63, Issue 5, pp 1143–1147 | Cite as

Latent Hepatitis Virus Reactivation Due to Drug Reaction: DRESSed to Kill?

  • David Alexanian
  • Aleksandr Birg
  • Nicholas Volpicelli
  • Joseph Glass
  • Denis McCarthy
UNM Clinical Case Conferences
  • 36 Downloads

Keywords

Rash HHV-6 Human herpesvirus 6 DRESS Drug reaction with eosinophilia and systemic symptoms Viral hepatitis Virus reactivation Latent virus Corticosteroid therapy Ganciclovir 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Crado PR, Criado RFJ, Avancini JdM, Santi CG. Drug reaction with eosinophilia and systemic symptoms (DRESS)/Drug-induced Hypersensitivity Syndrome (DIHS): a review of current concepts. Ann Bras Dermatol. 2012;87:435–449.CrossRefGoogle Scholar
  2. 2.
    Whitley RJ. In: Baron S, eds. Medical Microbiology. 4th ed. Galveston, TX: University of Texas Medical Branch at Galveston; Chapter 68; 1996.Google Scholar
  3. 3.
    Shiohara T, Iijima M, Ikezawa Z, Hashimoto K. The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations. Br J Dermatol. 2007;156:1083–1084.CrossRefPubMedGoogle Scholar
  4. 4.
    International Committee on Taxonomy of Viruses. ICTV Master Species List 2011.Google Scholar
  5. 5.
    Johnson S, Mathews S, Hudnall SD. Human herpesvirus 6 lymphadenitis in drug rash with eosinophilia and systemic symptoms syndrome: a lymphoma mimic. Histopathology. 2017;70:1166–1170.CrossRefPubMedGoogle Scholar
  6. 6.
    Ferrero NA, Pearson KC, Zedek DC, Morrell DS. Case report of drug rash with eosinophilia and systemic symptoms demonstrating human herpesvirus-6 reactivation. Pediatr Dermatol. 2013;30:608–613.CrossRefPubMedGoogle Scholar
  7. 7.
    Isaacson E, Glaser CA, Forghani B, Amad Z, et al. Evidence of human herpesvirus-6 infection in 4 immunocompetent patients with encephalitis. Clin Infect Dis. 2005;40:890–893.CrossRefPubMedGoogle Scholar
  8. 8.
    Challoner PB, Smith KT, Parker JD, MacLeod DL, et al. Plaque-associated expression of human herpesvirus 6 in multiple sclerosis. Proc Natl Acad Sci USA. 1995;92:7440–7444.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Alvarez-Lafuente R, De las Heras V, BartoloméM Picazo JJ, Arroy R. Relapsing-remitting multiple sclerosis and human herpesvirus 6 active infection. Arch Neurol. 2004;61:1523–1527.CrossRefPubMedGoogle Scholar
  10. 10.
    Härmä M, Höckerstedt K, Lautenschlager I. Human herpesvirus-6 and acute liver failure. Transplantation. 2003;76:536–539.CrossRefPubMedGoogle Scholar
  11. 11.
    Charnot-Katsikas A, Baewer D, Cook L, David MZ. Fulminant hepatic failure attributed to infection with human herpesvirus 6 (HHV-6) in an immunocompetent woman: a case report and review of the literature. J Clin Virol. 2016;75:27–32.CrossRefPubMedGoogle Scholar
  12. 12.
    Picard D, Janela B, Descamps V, D’Incan M, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS): a multiorgan antiviral T cell response. Sci Transl Med. 2010;2:46ra62.  https://doi.org/10.1126/scitranslmed.30011.CrossRefPubMedGoogle Scholar
  13. 13.
    Tuqan W, Lee S, Hanson J, McCarthy D. Carbamazepine-Associated Hypersensitivity Colitis. Dig Dis Sci. 2018;63:334–337.  https://doi.org/10.1007/s10620-017-4881-7.CrossRefPubMedGoogle Scholar
  14. 14.
    Boussiotis VA. Molecular and biochemical aspects of the PD-1 checkpoint pathway. N Engl J Med. 2016;375:1767–1778.CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Blumberg BM, Mock DJ, Powers JM, Ito M, et al. The HHV6 paradox: ubiquitous commensal or insidious pathogen? A two-step in situ PCR approach. J Clin Virol. 2000;16:159–176.CrossRefPubMedGoogle Scholar
  16. 16.
    Fotheringham J, Akhyani N, Vortmeyer A, Donati D, et al. Detection of active human herpesvirus-6 infection in the brain: correlation with polymerase chain reaction detection in cerebrospinal fluid. Infect Dis. 2007;195:450–454.CrossRefGoogle Scholar
  17. 17.
    Flamand L, Gravel A, Boutolleau D, Alvarez-Lafuente R, et al. Multicenter comparison of PCR assays for detection of human herpesvirus 6 DNA in serum. J Clin Microbiol. 2008;46:2700–2706.CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    Traylen CM, Patel HR, Fondaw W, Mahatme S, et al. Virus Reactivation: a panoramic view in human infections. Future Virol. 2011;6:451–463.CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    Asthana AK, Lubel JS. Reactivation of latent viruses after treatment with biological therapies. Virus Adapt Treat. 2014;6:1–10.Google Scholar
  20. 20.
    Lopez-Serrano P, de la Fuente-Briongos E, Carrera- Alonso E, Perez-Calle JL, et al. Hepatitis B and immunosuppressive therapies for chronic inflammatory diseases: when and how to apply prophylaxis, with a special focus on corticosteroid therapy. World J Hepatol. 2015;7:539–547.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2018

Authors and Affiliations

  • David Alexanian
    • 1
  • Aleksandr Birg
    • 1
  • Nicholas Volpicelli
    • 1
  • Joseph Glass
    • 2
  • Denis McCarthy
    • 1
  1. 1.Division of Gastroenterology and HepatologyUniversity of New Mexico School of MedicineAlbuquerqueUSA
  2. 2.Department of PathologyUniversity of New Mexico School of MedicineAlbuquerqueUSA

Personalised recommendations