Digestive Diseases and Sciences

, Volume 49, Issue 11–12, pp 1906–1911 | Cite as

Cyclooxygenase-2 Expression in the Hereditary Mixed Polyposis Syndrome

  • Eli Brazowski
  • Faina Misonzhnick-Bedny
  • Paul RozenEmail author


Hereditary mixed polyposis syndrome (HMPS), characterized by hyperplastic, juvenile, admixed, serrated adenomas and eventually colorectal cancer, is managed by repeated polypectomy and surgery. We determined if HMPS polyps express cyclooxygenase-2 (COX-2). Nineteen recent HMPS polyps, from five family members, were stained for COX-2. Polyps’ epithelium and stroma and comparison tissues (normal colonic mucosa [9], sporadic juvenile polyps [18], colorectal cancers [3]) were quantified for COX-2 by: area of staining (0–3) × intensity (0–3). Epithelial, stromal, and total scores were evaluated in relationship to histology and dysplasia. HMPS polyps COX-2 mean epithelial (5.0 ± 3.0), stromal (6.9 ± 1.9), and total (11.8 ± 4.6) scores were significantly higher (P&<0.01) than sporadic juvenile polyps (0.6 ± 0.7, 3.1 ± 2.2, and 3.6 ± 2.2 respectively), while colorectal cancer scored 9, 9, and 18. There was a positive association (P&<0.01) among histology, degree of dysplasia, and COX-2 expression. COX-2 expression in HMPS polyps and its association with dysplasia suggest that chemoprevention might be a useful adjunct therapy.

chemoprevention colorectal cancer COX-2 familial polyps 


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Copyright information

© Springer Science+Business Media, Inc. 2004

Authors and Affiliations

  • Eli Brazowski
    • 1
  • Faina Misonzhnick-Bedny
    • 1
  • Paul Rozen
    • 2
    • 3
    Email author
  1. 1.Department of PathologyTel Aviv Medical CenterIsrael
  2. 2.Department of GastroenterologyTel Aviv Medical CenterTel AvivIsrael
  3. 3.Tel Aviv UniversityTel AvivIsrael

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