Cyclooxygenase-2 Expression in the Hereditary Mixed Polyposis Syndrome
- 41 Downloads
Hereditary mixed polyposis syndrome (HMPS), characterized by hyperplastic, juvenile, admixed, serrated adenomas and eventually colorectal cancer, is managed by repeated polypectomy and surgery. We determined if HMPS polyps express cyclooxygenase-2 (COX-2). Nineteen recent HMPS polyps, from five family members, were stained for COX-2. Polyps’ epithelium and stroma and comparison tissues (normal colonic mucosa , sporadic juvenile polyps , colorectal cancers ) were quantified for COX-2 by: area of staining (0–3) × intensity (0–3). Epithelial, stromal, and total scores were evaluated in relationship to histology and dysplasia. HMPS polyps COX-2 mean epithelial (5.0 ± 3.0), stromal (6.9 ± 1.9), and total (11.8 ± 4.6) scores were significantly higher (P&<0.01) than sporadic juvenile polyps (0.6 ± 0.7, 3.1 ± 2.2, and 3.6 ± 2.2 respectively), while colorectal cancer scored 9, 9, and 18. There was a positive association (P&<0.01) among histology, degree of dysplasia, and COX-2 expression. COX-2 expression in HMPS polyps and its association with dysplasia suggest that chemoprevention might be a useful adjunct therapy.
Unable to display preview. Download preview PDF.
- 1.Jaeger EEM, Woodford-Richens KL, Lockett M, Rowan AJ, Sawyer EJ, Heinimann K, Rozen P, Murday VA, Whitelaw SC, Ginsberg A, Atkin WS, Lynch HT, Southey MC, Debinski H, Eng C, Bodmer WF, Talbot IC, Hodgson SV, Thomas HJW, Tomlinson IPM: An ancestral Ashkenazi haplotype at the HMPS/CRAC1 locus on 15q13-q14 is associated with Hereditary Mixed Polyposis Syndrome. Am J Hum Genet 72:1261–1267, 2003CrossRefGoogle Scholar
- 4.Rossi DJ, Ylikorkala A, Korsisaari N, Salovaara R, Luukko K, Launonen V, Henkemeyer, Ristimäki A, Aaltonen LA, Mäkelä TP: Induction of cyclooxygenase-2 in a mouse model of Peutz-Jegher polyposis. Proc Natl Acad Sci USA 99:12327–12332, 2002Google Scholar
- 12.Benamouzig R, Deyra J, Martin A, Girard B, Julian E, Piednoir B, Couturier D, Coste T, Little J, Chaussade S, for The Association Pour La Prevention Par L’ Aspirine due Cancer Colorectal Study Group: Daily soluble aspirin and prevention of colorectal adenoma recurrence: One-year results of the APACC trial. Gastroenterology 125:328–336, 2003CrossRefGoogle Scholar