Digestive Diseases and Sciences

, Volume 49, Issue 11–12, pp 1875–1881 | Cite as

GABAergic Mechanisms of Gastroprotection in the Rat: Role of Sensory Neurons, Prostaglandins, and Nitric Oxide

  • Richard F. HartyEmail author
  • Hanumantha R. Ancha
  • Yang Xia
  • Mark Anderson
  • Ahmad Jazzar


γ-Aminobutyric acid (GABA) is a neurotransmitter found in both the central and the peripheral nervous systems including the gastrointestinal tract. The aims of the present studies were to examine mechanisms by which GABA exerts gastroprotective effects against ethanol- and water-restraint stress (WRS)–induced gastric mucosal injury in the rat. GABA, administered intragastrically (400 mg/kg), induced gastroprotection against ethanol and WRS by activating gastric sensory neurons to release calcitonin gene-related peptide (CGRP) and promote nitric oxide (NO) synthesis and release. Furthermore, these protective effects of GABA were associated with an increase in gastric mucosal blood flow (GMBF) that was dependent on sensory neuron and NO systems. GABA-mediated protection involved GABAA receptor activation and prostaglandin generation. In conclusion, intraluminal GABA protects the stomach against ethanol- and WRS-induced injury by mechanisms which involve sensory neuron/CGRP/NO pathways and increases in GMBF and prostaglandin generation.

γ-aminobutyric acid calcitonin gene-related peptide nitric oxide prostaglandins gastric ulcer Rat-5 


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Copyright information

© Springer Science+Business Media, Inc. 2004

Authors and Affiliations

  • Richard F. Harty
    • 1
    Email author
  • Hanumantha R. Ancha
    • 1
  • Yang Xia
    • 1
  • Mark Anderson
    • 1
  • Ahmad Jazzar
    • 1
  1. 1. Division of Gastroenterology, Department of MedicineUniversity of Oklahoma Health Sciences Center and Oklahoma City Department of Veterans Affairs Medical CenterOklahoma CityUSA

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