Oral S(+)-Ketamine Does Not Change Visceral Perception in Health
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Application of N-methyl-d-aspartate (NMDA)-receptor antagonists may hold promise for the treatment of visceral pain. In this study we evaluated the effect of oral S(+)-ketamine (sKET), a noncompetitive NMDA-receptor antagonist, on visceral sensitivity in healthy volunteers. Eight healthy volunteers (five male, three female) underwent a gastric barostat study following oral administration of placebo, 25 mg sKET, and 50 mg sKET. Studies were performed in a double-blind randomized crossover fashion. Sensations evoked by stepwise isobaric distension (2 mm Hg/2 min) were scored on a 100-mm visual analogue scale. In addition, fasting and postprandial fundic volume were measured at a fixed pressure level (MDP + 2 mm Hg). During gastric distension, sKET did not alter sensation scores for bloating, nausea, satiation, and pain compared to placebo. sKET had also no effects on the thresholds for pain/discomfort, fundic wall compliance, fundic tone, or meal-induced fundic relaxation. sKET does not reduce visceral perception or gastric motility in healthy volunteers. The role of sKET in conditions characterized by visceral hypersensitivity needs to be studied further.
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- 4.Kirkup AJ, Brunsden AM, Grundy D: Receptors and transmission in the brain-gut axis: Potential for novel therapies. I. Receptors on visceral afferents. Am J Physiol 280:G787–G794, 2001Google Scholar
- 5.Bueno L, Fioramonti J, Garcia-Villar R: Pathobiology of visceral pain: molecular mechanisms and therapeutic implications. III. Visceral afferent pathways: A source of new therapeutic targets for abdominal pain. Am J Physiol 278:G670–G676, 2000Google Scholar
- 12.McRoberts JA, Coutinho SV, Marvizon JC, Grady EF, Tognetto M, Sengupta JN, Ennes HS, Chaban VV, Amadesi S, Creminon C, Lanthorn T, Geppetti P, Bunnett NW, Mayer EA: Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats. Gastroenterology 120:1737–1748, 2001CrossRefPubMedGoogle Scholar
- 21.Azpiroz F, Malagelada J-R: Physiological variations in canine gastric tone measured by an electronic barostat. Am J Physiol 247:229–237, 1985Google Scholar