, Volume 71, Issue 2, pp 647–663 | Cite as

Mitochondrial transplantation as a potential and novel master key for treatment of various incurable diseases

  • Amaneh Mohammadi Roushandeh
  • Yoshikazu Kuwahara
  • Mehryar Habibi RoudkenarEmail author


Mitochondria are attractive cellular organelles which are so interesting in both basic and clinical research, especially after it was found that they were arisen as a bacterial intruder in ancient cells. Interestingly, even now, they are the focus of many investigations and their function and relevance to health and disease have remained open questions. More recently, research on mitochondria have turned out their potential application in medicine as a novel therapeutic intervention. The importance of this issue is highlighted when we know that mitochondrial dysfunction can be observed in a variety of diseases such as cardiovascular diseases, neurodegenerative diseases, ischemia, diabetes, renal failure, skeletal muscles disorders, liver diseases, burns, aging, and cancer progression. In other words, transplantation of viable mitochondria into the injured tissues would replace or augment damaged mitochondria, allowing the rescue of cells and restoration of the normal function. Therefore, mitochondrial transplantation would be revolutionary for the treatment of a variety of diseases in which conventional therapies have proved unsuccessful. Here, we describe pieces of evidence of mitochondrial transplantation, discuss and highlight the current and future directions to show why mitochondrial transplantation could be a master key for treatment of a variety of diseases or injuries.


Mitochondria dysfunction Reactive oxygen species Neurodegenerative diseases Heart failure Mitochondrial transplantation 



Part of this study was supported by National Institute for Medical Research Development (Grant No. 962134).

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.


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© Springer Nature B.V. 2019

Authors and Affiliations

  • Amaneh Mohammadi Roushandeh
    • 1
  • Yoshikazu Kuwahara
    • 2
  • Mehryar Habibi Roudkenar
    • 3
    • 4
    Email author
  1. 1.Medical Biotechnology Department, Paramedicine FacultyGuilan University of Medical SciencesRashtIran
  2. 2.Divisions of Radiation Biology and Medicine, Faculty of MedicineTohoku Medical and Pharmaceutical UniversitySendaiJapan
  3. 3.Department of Cardiology, Cardiovascular Disease Research Center, Heshmat Hospital, School of MedicineGuilan University of Medical SciencesRashtIran
  4. 4.Stem Cell and Regenerative Medicine Research CenterGuilan University of Medical SciencesRashtIran

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