Chemical Constituents of the Stem Bark of Daphne altaica
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Daphne altaica is a deciduous herb of the Thymelaeaceae family. It is endemic to the north of Jungar Basin of Xinjiang, China (the Tacheng and Habahe areas), Altai, Manrak, and Tarbagatai Mountains of Kazakhstan, and Altai region of Russia, as well as northwest Mongolia . D. altaica has been used in traditional Kazakh medicine for the treatment of many diseases like esophaged cancer, gastric cancer, tracheitis, common cold, soar throat, rheumatism, and snakebite . We have previously reported that D. altaica has antiproliferative activities against several cancer cells in vitro [1, 2]. In the present study, nine compounds were isolated from the EtOAc extract of the stem bark of D. altaica, together with two compounds from its CH2Cl2 extract.
D. altaica was collected from Habahe County of Xinjiang, China in August, 2017. The dried and shredded stem barks of D. altaica(4.0 kg) were extracted with 95% EtOH at a herb–EtOH ratio of 1:5 (w/v) using heat reflux extraction. This...
This study was supported by National Natural Science Foundation of China (Grant No. 81360499) and Training Project for Scientific and Technological Talents of Xinjiang Uighur Autonomous Region (Grant No. QN2016YX0759).
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